Cardio U

Question 1

Hydralazine

MOA, Clinical use, special, SE

Answer 1

MOA: inc. cGMP => relax s.m => VD (artery > veins)
Special: high protein bound, no effect on sympathetic so use beta blocker with it (reflex tc)
Clinical use:
1- sever HT (acute)
2- HF (with organic nitrates)
3- pregnancy
SE:
1- compensatory tc => CI in angina and CAD
2- fluid retention, headache
3- angina
4- SLE like syndrome

Question 2

Nitro-prusside

Special, MOS, SE

Answer 2

Special: hypertensive emergency
MOA: short acting VD (a=v) , inc cGMP via direct release of NO
SE: can cause cyanide toxicity! (Release cyanide)

Question 3

Names and classification of calcium channels blocker

Answer 3

Dihydropyridines:
امل و نيڤي ركبو السيارة في الطريق (BV) عشان يشوفو سمكة نيمو
Act on BV

Non-dihydro: verapamil + deltiazem => act on heart

Question 4

MOA of ca channel blocker , clinical use

Answer 4

Block L-type ca channel on heart and BV => dec muscle Contractility 
Clinical use: 
#dihydrppyridine: HT, angina ( include vasospastic) raynaud phenomena