Case Study: 1974 Paper--Reserpine and Breast Cancer Flashcards Preview

Pharmacoepidemiology > Case Study: 1974 Paper--Reserpine and Breast Cancer > Flashcards

Flashcards in Case Study: 1974 Paper--Reserpine and Breast Cancer Deck (11):
1

Study Population

Hospitalized patients from 24 Boston area hospitals (n = 25 thousand admitted to general medical and surgical wards)

2

Study Population (Exclusion)

Those admitted in last 3 months, too ill, in hospital

3

Study Design

Case-Control

4

Exposure assessment

Patient Interview shortly after admission: asked about medications in 3months for 26 indications

5

Outcome assessment

From hospital discharge records

6

Sample size

150 cases, 1200 controls

7

Cases

Medical/surgical patients with discharge of incident BC, REMEMBERED names of AHDs

8

Controls

4 medical/4surgical patients per case, matched by decade of age &hospital. No 1st discharge diagnosis of any cancer or for medical patients, CVD and finally, remembered names of AHDs

9

Association

Yes, RR = 3.5 (1.6, 8.0)

10

Potential Biases

Confounding? Selection? Chance may be most likely

11

What control sampling method was used in both 1974 and 1984 paper?

Cumulative incidence sampling