Cell Mediators

Question 1

Serotonin PA and origin

Answer 1

Vasodilation, increased vascular permeability

Platelets

Question 2

Prostaglandins PA and O

Answer 2

PA: Vasodilation, Pain, Fever

O: mast cells, leukocytes

Question 3

Leukotrienes PA and O

Answer 3

PA: last longer. Vasodilation, inc vascular permeability

O: mast cells, leukocytes

Question 4

Platelet activating factor PA and O

Answer 4

O: Leukocytes, endothelial cells

PA: Vasodilation, increased vascular permeability, chemotaxis

Question 5

Reactive oxygen species PA and O

Answer 5

PA: kill microbes, damage tissue

O: leukocytes

Question 6

Nitric oxide PA and O

Answer 6

PA: relax vascular smooth muscle, kill microbes

O: endothelium, macrophage

Question 7

Cytokines (TNF, IL-1) PA and O

Answer 7

PA: local endothelial activation (adhesion molecule expression) systemic acute phase response.

O: macrophages, lymphocytes, endothelial cells, mast cells

Question 8

Chemokines PA and O

Answer 8

PA: leukocytes chemotaxis and activation

O: leukocytes, activated macrophages

Question 9

Histamine Principal Action and Origin

Answer 9

Vasodilation, inc Vascular Permeability

Origin: Mast cells, basophils, platelets