Ch. 36 Insect Bites, Stings, and Pediculosis Flashcards

1
Q

Insect Bites, Stings, and Pediculosis

A
  • 0.5% shown to have systemic reactions to insect stings
  • 500+ stings can cause death from toxicity
  • Pediculosis - lice infestation, effects 10-12 million per year, mostly kids from 3-12 y.o.
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2
Q

Insect Bites

A

Nonvenomous, but have biting organs and saliva secretions that cause reactions

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3
Q

Mosquitoes

A
  • Found mainly in warm, humid climates
  • Inject anticoagulant into victim causing the welt and itching
  • Malaria and West Nile Virus are severe systemic infections transferred by mosquitoes
  • 2012- 48 states reported W.N.V. - 20% of infected experienced fever and fatigue
  • Can progress to muscle weakness, encephalitis, and meningitis
  • Control mosquito population to prevent disease spread
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4
Q

Fleas

A
  • Tiny bloodsuckers found worldwide but breed best in humid climates
  • Usually bitten by moving into a flea infested area or by having infested pets
  • Usually multiple, grouped bites around legs/ankles
  • Erythematous, itchy around puncture
  • Can transmit bubonic plague and endemic typhus
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5
Q

Sarcoptes Scabiei

A
  • Scabies, “the itch,” contagious parasite infection caused by sarcoptes scabiei
  • Very small, rarely seen arachnid mite
  • Burrow up to 1 cm in skin, deposit eggs
  • Common between fingers, on wrists, on butt, on penis, and in anterior armpit folds
  • Inflammation and intense itching
  • Transferred by contact and can only be treated by Rx
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6
Q

Bedbugs

A
  • hide and deposit eggs in walls, floors, picture frames, bedding, folds of linens, corners of suitcases, and furniture during day
  • Bite their victims at night
  • Increase mobility of people has increased the incidence of these infection
  • Bites usually around head, neck, and usually cluster in 2-3 in a straight line
  • Reaction can be anywhere from irritation to a small dermal hemorrhage
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7
Q

Ticks

A
  • Feed on human and animal blood
  • Ticks mouthparts are introduced into skin making it hold tightly
  • If mouthparts aren’t removed when the tick is, intense itching and nodules requiring surgery may develop
  • If left attached, tick becomes engorged and remains for up to 10 days on the skin before falling off
  • Remove intact tick within 36 hours of attachment
  • Don’t use heat methods, nail polish, or petrolatum to remove tick since it can irritate it and increase its saliva secretions or cause it to regurgitate its contents
  • Can cause itching papules for up to 1 week
  • Some carry Rocky Mountain Spotted Fever and Lyme Disease
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8
Q

Rocky Mountain Spotted Fever

A
  • Severe headache, rash, fever, exhaustion

- Spread by dog or wood ticks

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9
Q

Lyme Disease

A
  • Cause by spirochete
  • Spread by deer ticks
  • Transmitted after being attach for 36 hours
  • Common in NE/Midwest parts of U.S., reported in 46 states
  • 1st: papule, then enlarged circle with a clear center called a “bulls-eye”
  • Tender, urticarial lesion appears 3-32 days later and spontaneously disappears within 3-4 weeks
  • If untreated, neurological symptoms, cardiac disturbances, and musculoskeletal symptoms and arthritis can occur
  • Early diagnosis and health care treatment is needed to prevent these severe results
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10
Q

Chiggers

A
  • AKA red bugs, live in shrubs, trees, and grass
  • Attach to skin and larvae secrete digestive fluid to cause cellular disintegration
  • Creates red papule and intense itching
  • Also causes skin hardening that forms a tube for a chigger to engorge until it drops off and becomes an adult
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11
Q

Spiders

A
  • All are poisonous but most can’t penetrate the skin due to short or fragile fangs
  • Black widow, brown recluse, and hobo spiders are exceptions
  • Death: rare, but symptoms are serious
  • Black widow: delayed, intense pain, stiffness, joint pain, abdominal disturbances, fevers, chills, dyspnea
  • Brown recluse: same symptoms but also a spreading, ulcerated wound at the bite site
  • Hobo: moderate to severe, slow healing wound
  • If spider bite is suspected but not confirmed, monitor wound area for symptoms
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12
Q

Insect Bite Complications

A
  • Secondary infections from itching

- Includes impetigo - yellow crusting, purulent discharge, significant redness and swelling

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13
Q

Insect Bite Treatment

A

Non-Rx external analgesics for minor bug bites

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14
Q

Insect Bite Treatment Goals

A
  • Relieve symptoms

- Prevent secondary infections

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15
Q

Insect Bites General Treatment

A
  • Apply ice pack wrapped in a wash cloth to provide pain/irritation relief
  • Apply for 10 minutes and space out at least 10 minutes between applications
  • Use non-Rx topical analgesic if this doesn’t work
  • Avoid scratching
  • Okay to self treat if reaction ins confined to bite site and patient is > 2 y.o.
  • Doctor referral: scabies, ticks, and spiders
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16
Q

Insect Bite Nonpharmacologic

A
  • Prevention
  • Insect repellant
  • Avoiding insects
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17
Q

Insect Bite Avoidance

A
  • Cover skin as much as possible
  • Avoid swamps, dense woods, dense brush,
  • Keep pets pest free
  • Remove standing water from home
  • Limit time outside at dusk and dawn
  • Use window screens and netting
  • Avoid infected individuals
  • Apply insect repellant
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18
Q

Insect Repellant

A
  • Don’t repel stinging insects
  • Choose based on ingredients, concentrations, and types/lengths of exposure
  • DEET: 7-100%, may be combined with IR3535 or dimehthyl phthalate
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19
Q

DEET

A
  • Best all purpose repellant
  • MOA: not fully understood, doesn’t kill insects
  • Releases vapors that discourage insects
  • Sprays, solution, wipes, creams, and other forms
  • Frequency: q 4-8 h, on skin and cloths
  • Use >30% for kids, non in less than 2 months
  • 10-40% is adequate for adults in routine situations, 50-100% usually for adults in high, extended time exposure
  • Higher concentrations have higher tendencies of skin reactions
  • Heat and humidity can lower its efficacy
  • Improper use/ingestion can lead to seizures, ataxia, hypotension, angioedema, encephalopathy
  • Safe when properly used, even preggo/BF
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20
Q

Other Repellants

A
  • Citronella, lemon eucalyptus oil, soybean oil, cedar oil, lavender oil, tea tree oil, garlic, thiamin, and scented moisturizers in minieral oil
  • Less effective than DEET, especially regarding length of action
  • Picaridin, alternative to DEET, promoted as having less odor and irritation, 0.5%, only for clothes/camping equipment
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21
Q

Insect Bites Pharmacologics

A
  • Some local anesthetics, topical antihistamine, hydrocortisone, and counterirritants are approved for pain/itching
  • Topical protectants can be used to reduce inflammation and increase healing
  • Antiseptics and antibiotics can help prevent infection
  • Systemic antihistamines often used for bite itching but not an indication
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22
Q

Insect Bites - Local Anesthetics

A
  • Benzocaine, pramaxine, benzyl alcohol, lidocaine, dibucaine, and phenol - approved for itching and irritation relief
  • Cause reversible blockade on nerve impulse conduction and site
  • Phenol depresses cutaneous sensory receptors
  • Topical preparations are applied 3-4x per day for a max of 7 days
  • Usually well tolerated with minimal systemic absorption other than allergic dermatitis
  • Pramoxine and benzyl alcohol have less SE
  • Dibucaine - common allergen that can cause systemic toxicity resulting in convulsions, myocardial depression, and death
  • Phenol solutions >2% - irritating and can cause sloughing of skin and necrosis
  • Don’t apply phenol to extensive areas of body of under compresses/bandages, don’t use in preggo or children
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23
Q

Insect Bites - Topical Antihistamines

A
  • Diphenhydramine - 0.5-2% most popular topical antihistamine agent
  • Depresses cutaneous receptors and approved for temporary relief of pain/itching
  • Many dosage forms, 3-4x per day with a max of 7 days
  • Usually not absorbed enough to cause systemic SE
  • Systemic absorption increases with extensivearea use and kids
  • SE: photosensitivity, allergic reactions, continued use for 3-4 weeks can increase contact dermatitis risk
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24
Q

Insect Bites - Counterirritants

A
  • Low concentrations used in topical analgesics

- Generally appled 3-4x per day for up to 7 days

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25
Q

Insect Bites - Camphor

A
  • 0.1-3%, depresses cutaneous receptors and relieves itching and irritation (anesthetic effect)
  • VERY dangerous if ingested
  • Keep out of kid’s reach
26
Q

Insect Bites - Menthol

A
  • Concentrations <1% depresses cutaneous receptors and exert analgesic effect
  • Considered safe and effective antipruritic when applied to effect area at 0.1-1%
27
Q

Insect Bites - Hydrocortisone

A
  • 1% indicated for temporary relief of minor bites
  • Many dosage forms
  • Apply to bite 3-4x day for a max of 7 days
28
Q

Insect Bites - Skin Protectants

A
  • Zinc oxide, calamine, and titanium dioxide are applied to bites as cream/lotion/ointment
  • Act as protectants and decrease inflammation/irritation
  • Zinc oxide: acts as mild astringent with weak antiseptic properties, absorbed fluids from weeping lesions
  • Calamine - absorbed fluids from weeping lesions
  • Calamine and zinc oxide are effective at 1.25%
  • Titanium dioxide: similar MOA as zinc, biut its safety and efficacy aren’t established
  • Apply to AA prn, minimal adverse effects, and recommended for adults, kids, and infants
29
Q

Insect Bites - Product Selection Guideline

A
  • Sensitization can occur with local anesthetics
  • If these are preferred, praoxime and benzyl alcohol have lowest incidence of ASE
  • Phenol and dibucaine have the highest rate of ASE
  • ASE and systemic absorption are not a concern with short-term use of topical antihistamines, prolonged use can cause photoallergic or allergic reactions
  • Short-term hydrocortisone use is usually okay too
  • Scabies, bacterial/fungal infections - don’t use hydrocortisone without medical supervision since it can worsen or mask the disorder
  • Camphor: dangerous if ingested, not for kids
  • Don’t use any product for more than 7 days
  • Dosage form preference can also guide selections
30
Q

Insect Bites Assessment

A
  • Determine type of insect bite first
  • Spider/tick - medical referral
  • Serious reactions - medical referral
  • Nonallergic reactions: appropriate for external analgesic for symptomatic relief and skin protectant to decrease irritation/inflammation is appropriate
31
Q

Insect Bites Counseling

A
  • Treating injury and preventing future bites
  • Nondrug measures and proper use
  • Include potential SE and signs/symptoms that require medical intervention
  • Appropriate repellant use
32
Q

Insect Bite Evaluation

A
  • Follow-up: after 7 days of self treatment
  • Seek medical attention if redness, itching, or swelling occurs during drug treatment
  • Secondary infection, fever, joint pain, or lymph node enlargement are reasons to see a doctor
  • Medical intervention if symptoms persist after 7 days
33
Q

Insect Strings: Pathophysiology/Presentation

A
  • Order Hymenoptera - bees, wasps, hornets, yellow jackets, and fire ants
  • Attack victims to defend themselves or kill insects
  • Inject venom with allergenic proteins and pharmacologic active molecules - varies between species
  • Most complain of itching, pain, and irritation at site of sting with no systemic symptoms
  • Allergic reactions: gives, itching, swelling, burning sensations, anaphylaxis (RARE, but can cause light-headedness, best tightness, drops in BP)
34
Q

Wild Honeybees/Wasps/Hornets/Yellow Jackets

A
  • Honeybees: West/Midwest, usually nest in tree trunks, stingers are barbed and stay in skin to keep injecting venom
  • Paperhawks/Hornets/Yellow Jackets: South, central, and SW U.S., stingers aren’t barbed allowing for multiple stings
  • Paper wasps - nest in high places
  • Hornets - nest in hollow places like trees
  • Yellow Jackets - nest in low places like cracks in sidewalks or small shrubs, usual stinging culprits
35
Q

Fire Ants

A
  • Imported from South America, now in South/West U.S.
  • Live in underground colonies with raised mounds
  • Some only bite while others bite AND sting, bite is believed to cause reactions
  • Can cause intense itching, burning, vesiculation, tissue necrosis, and anaphylaxis
36
Q

Insect Sting Treatments

A

-Similar products for bites can be used for stings

37
Q

Insect Sting Treatment Goals

A
  • Relieve itching and pain of nonallergic reactions

- Allergic reactions require medical referral

38
Q

Insect Sting General Approach

A
  • Remove stinger, apply ice pack (10 minutes intervals), apply local anesthetics, skin protectants, or counterirritants - appropriate when confined to site
  • Avoid future stings to prevent allergy development
  • Wear allergy bracelet or card to identify allergies if they have them
  • Contact PCP for EpiPen script if allergies develop
39
Q

Insect Sting Nonpharmacologic

A
  • Ice pack, 10 minutes intervals, decrease absorption, itching, swelling, and pain
  • Remove stinger/venom sac, preferably within 2-3 minutes so that venom isn’t fully injected
  • Scratch away stinger with fingernail or credit card
  • Apply antiseptic after stinger is removed (hydrogen peroxide)
  • Avoid attracting stinging insects: wear shoes, avoid perfume, bright clothes control food odors, change clothes if food gets onto it
40
Q

Insect Stings Pharmacologic

A
  • Same topicals as insect bites

- Systemic antihistamines often used for sting itching, not indicated for it

41
Q

Insect Sting Complementary Therapies

A
  • Meat tenderizers - break down venom proteins
  • Ammonia/baking soda - neutralize venoms
  • Anecdotal success that may effect itching, efficacy not determined
42
Q

Insect Sting Assessment

A
  • Assess if allergic to venom

- Refer to PCP if allergic reaction is occurring

43
Q

Insect Sting - Counseling

A
  • Reactions usually transient, but can become allergic with repeated exposure
  • Epinephrine should be available to those who are allergic
  • Nonallergic reactions should be recommended one or more topicals for symptom relief
  • Advise about ASE and CI
44
Q

Insect Sting - Evaluation

A
  • Follow up within 7 days
  • Seek medical attention if pain, itching, and local swelling worsens during treatment or if it persists after 7 days of treatment
  • Secondary infection and fever should be referred to doctor
  • Allergic reactions: follow up the same day
45
Q

Pediculosis

A
  • Lice and infestations in U.S. are common

- 3 types: head lice, body lice, and pubic lice

46
Q

Head Lice

A
  • Most common, outbreaks usually happen in schools or day care centers
  • Spreads with close personal contact or sharing personal items like caps, hairbrushes, and combs
  • Peaks around August - November
  • All socioeconomic groups effects
  • Don’t spread other diseases
  • Infest head and live on scalp, lice egg or nit ~1 mm in diameter and found within 4 mm of scalp
  • Once hatched, needs to feed within 24 hours else they die
  • Matures into an adult within 8-9 days
  • Without treatment, cycle repeats in 3 weeks
  • Bites cause immediate wheals with papules appearing within 24 hours
  • Itching/scratching can lead to secondary infections
  • Nits/nit casings generally are spotted at the base of hair shafts, inspect the crown of head, near ears, and base of neck for these casings
  • Firmly attached to nit/nit casings and their presence can indicate an infestation
47
Q

Body Lice

A
  • “Cooties,” live, hide, and lay eggs in clothing
  • Periodically attach to body for blood feeding and can transmit typhus and trench fever
  • Usually occur in those who don’t shower or change clothes regularly, like the homeless
48
Q

Public Lice

A
  • AKA crabs, usually spread from sexual contact
  • Can also spread from toilet seats, sharing underwear, or bedding
  • Can also infect armpits, eyelashes, mustaches, beards, and eyebrows
49
Q

Lice Treatment

A
  • Non-Rx pediculicide agents
  • Hair combing for nit removal
  • Home vacuuming and cleaning or personal items
50
Q

Lice Treatment Goals

A
  • Killing adult/nymph lice

- Removing nits from patient’s hair

51
Q

Lice General Treatment

A
  • Pediculicide on infected body area
  • Hair combing
  • Avoidance of future infestations
52
Q

Lice Nonpharmacologic

A
  • Careful visual inspection with nit comb, like LiceMeister comb, to remove nits are helpful for treating/controlling lice
  • Avoid contact with infested individual
  • Wash clothing/bedding with hot water and dry in dryer to kill lice/nits
  • May also seal in plastic bag for 2 weeks
  • Hairbrushes/combs - wash in hot water
  • Vacuum carpets, rugs, furniture regularly and thoroughly
  • May also shave head to help get rid of lice
  • Body lice: appropriate body hygiene and frequent changing/laundering of clothes/linens
53
Q

Lice Pharmacologic

A
  • Permethrins or synergized pyrethrins
  • Don’t overuse due to increasing resistance
  • Resistance due to overuse, improper use, or insufficient contact times can occur
54
Q

Synergized Pyrethrins

A
  • Approved for head/public lice
  • Add a piperonyl butoxide
  • Block nerve impulse transmission leads to insect paralysis and death
  • Piperonyl butoxide: inhibits pyrethrin breakdown with increases insecticide concentrations
  • Excessive contact can increase systemic absorption
  • Pyrethrins: 0.17-0.33% + Piperonyl Butoxide: 2-4%
  • Effected pediculicide topically as a shampoo, foam, solution, of gel
  • AAA for 10 minutes, then rinse/shampoo as recommended
  • Comb following treatment
  • Repeat in 7-10 days to kill remaining nits that have hatched
  • Don’t apply more than twice per 24 hours
  • Low toxicity when applied correctly
  • ASE: irritation, erythema, itching, swelling
  • Avoid eye and mucus membrane contact
  • Avoid if allergic to pyrethrins, chrysanthemums, or ragweed (cross sensitivity)
55
Q

Permethrin

A
  • Synthetic pyrethroid for non-Rx cream rinse for head lice ONLY
  • Act on nerve cell membrane, disrupts sodium channels, leads to paralysis and death
  • When applied, <2% absorbed systemically which is then metabolized
  • 1% cream rinse should be applied in sufficient quantity to cover/saturate washed hair and scalp
  • Leave on for 10 minutes then rinse and comb with lice comb
  • Treatment has a residual effect for up to 10 days, so 2nd wash isn’t necessary
  • ASE: pruritis, burning, stinging, scalp irritation occurs in 10% of population
  • Avoid eye and mucus membrane contact
  • CI: hypersensitivity to pyrethrins/chrysanthemums, don’t use in less than 2 months
56
Q

Lice - Pharmacotherapeutic Comparison

A
  • Single application: permethrin is more effective

- Two applications: no significant difference in efficacy between the products

57
Q

Lice Product Selection Guidelines

A
  • Pyrethrins: 2 y.o. or older, used in preggo and BF only if prescribed by doctor, may be recommended for public lice too
  • Can use either for head lice based on preference of dosage forms, allergies, and desire for single applications or not
58
Q

Lice Complementary Therapies

A
  • Lice enzyme shampoos, breakdown lice exoskeleton
  • Product with 10% tea tree oil and 1% lavender oil application
  • Application every week for 3 weeks was found to be more effective than non-Rx applied twice
  • Tea tree oil: use with caution due to allergic reaction and possible toxicity
  • Other oil based products like petrolatum and mayonnaise are also used to impair respiration, but no effective and likely just to slow them down
  • Avoid using gasoline or kerosene
59
Q

Lice Emerging Therapies

A
  • DSP lotions (Cetaphil): new product study, nontoxic lotion that “shrink wraps” lice
  • Applied to hair and dried with hair dryer, cover breathing holes and suffocates louse
  • Dimethicone 4% lotion: cures pediculosis and causes less irritation, coats lice and immobilizes them within 5 minutes of application
  • LouseBuster applies heat to hair/scalp which dehydrates lice/nits leading to their death
  • Kills ~90% or more of nits, but expensive and requires technician to operate the machine
60
Q

Lice Assessment

A
  • Visual inspection of scalp
  • Body lice: identifying adult lice in clothing seams
  • Don’t recommend pediculicide in those without inspection confirmation
  • Recommend pediculicide once inspection confirms lice infestation
61
Q

Lice Counseling

A
  • Pharm + nonpharm interactions needed
  • Head lice isn’t from poor hygiene
  • Discuss products, proper use, and preventable measures
62
Q

Lice Evaluation

A
  • Follow up: 10 days
  • If signs of infestation persist after pediculicide treatment, refer to PCP
  • Discourage overuse of pediculicide and emphasize nonpharmacologic measures