Chapter 25 Flashcards

1
Q

difference between infection and disease

A

Infection: whether or not host is harmed it is a microbe growing in a host
disease: injury to organism affection host functions

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2
Q

what is pathogenicity

A

the ability of a parasite to inflict damage

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3
Q

what is adherence

A

enhanced microbial ability to attach to host (it is necessary but not sufficient for disease)

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4
Q

INFECTION AND DISEASE PROCESS CHART

A

INFECTION AND DISEASE PROCESS CHART

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5
Q

what are receptors in regards to pathogens

A

many ones coat pathogens and tissues and it is where pathogens can bind

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6
Q

what proteins are responsible for adhesins

A

glycoproteins or lipoproteins on pathogen surface

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7
Q

Characteristics of capsules

A

FIRST it is an adherence structure
sticky, has specific receptors that can facilitate attachment to host tissues, can protect microbes from ingestion by white blood cells

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8
Q

other adherence structures

A

fimbriae, pili, flagella

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9
Q

how does colonization occcur

A

gain access to host tissues and growth of microorganisms
typically starts with mucous membranes
secretion of protein and glycoprotein

CUTS WOUNDS and punctures also provide access to microbes

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10
Q

what are dental caries

A

an oral microbial disease caused by streptococcus

S. sobrinius and S. mutans) that make contact with tooth surface and reproduce and form a biofilm (called a plaque

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11
Q

what are biofilms

A

planktonic growth: growth as suspension

sessile growth: grow while attached to surface and can developed into biofilms

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12
Q

how are biofilms formed

A

sessile growth: attached polysaccharide matrix that can contain other macromolecules (i.e. protein, DNA, lipids)

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13
Q

functionalities of biofilms

A

prevents harmful chemicals from penetrating, prevent protists from grazing (white blood cells) phagocytosis (engulfment) is hindered and also prevents washing away of cells

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14
Q

how to judge invasiveness

A
  1. ability of growth in host tissue

2. the growth reaches densities that inhibit host functions

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15
Q

what is bacteremia

A

presence of bacteria in bloodstream

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16
Q

what is speticemia

A

bloodborne systemic infection

17
Q

what can speticemia lead to

A

massive inflammation
septic shock
death

18
Q

what is virulence

A

relative ability to cause diseases

19
Q

what do highly virulent pathogens show

A

show little difference in LD (lethal doses) of LD-50 (50%) and LD-100. cell number not that much different

20
Q

what is attenuation

A

decrease or loss of virulence

21
Q

how is attenuation aluable to clinical medicine

A

attenuated strains used for production of vaccines (especially viral)

22
Q

What is a compromised host

A

1 or more resistance mechinisms are inactive
probability of infection increases in host
ex: cancer, HIV, hospital patients that go through invasive medical procedures, surgery.