Chapter 3 - Development Flashcards

1
Q

Where does fertilization usually occur?

A

In the ampulla of the fallopian tube.

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2
Q

What is the difference between Determinative Cleavage and Indeterminate Cleavage?

A

Determinate refers to cell division that results in cells having definite lineages. Indeterminate refers to cell division that results in cells that can differentiate into any cell type (or a whole organism).

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3
Q

From zygote to gastrula, what are the various stages of development? (5)

A
  1. Zygote
  2. 2-,4-,8-, and 16-cell embryo
  3. Morula
  4. Blastula (blastocyst)
  5. Gastrula
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4
Q

What’s the difference between Fraternal (dizygotic) twins and Identical (monozygotic) twins?

A

Fraternal twins result from the fertilization of two eggs by two different sperm. Identical twins result from a zygote splitting in two.

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5
Q

During which stage of development does implantation occur?

A

Blastula (blastocyst) stage. The blastula implants in the endometrial lining and forms the placenta.

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6
Q

What is Gastrulation?

A

The generation of three distinct cell layers: the primary germ layers.

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7
Q

What are the three primary germ layers?

A
  1. Ectoderm
  2. Mesoderm
  3. Endoderm
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8
Q

What does the Ectoderm account for?

A

It becomes the epidermis, hair, nails, and the epithelia of the nose, mouth, and anal canal, as well as the nervous system (including adrenal medulla).

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9
Q

What does the Mesoderm account for?

A

Becomes much of the musculoskeletal, circulatory, and excretory systems. Also gives rise to the gonads, tissue layers of the digestive and respiratory tracts, and the adrenal cortex.

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10
Q

What does the Endoderm account for?

A

Becomes much of the epithelial linings of the respiratory and digestive tracts, and parts of the pancreas, thyroid, bladder, and distal urinary tracts.

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11
Q

What is Induction and how does it influence development?

A

Induction is the process by which nearby cells influence the differentiation of adjacent cells. This ensures proper spatial location and orientation of cells that share a function or have complementary functions.

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12
Q

What tissues do neural crest cells develop into?

A

Neural crest cells become the peripheral nervous system (including the sensory ganglia, autonomic ganglia, adrenal medulla, and Shwann cells) as well as specific cell types in other tissues (such as calcitonin-producing cells of the thyroid, melanocytes in the skin, and others).

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13
Q

What is Neurulation?

A

Development of the Nervous System. Begins after the formation of the three germ layers.

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14
Q

What are Teratogens?

A

Substances that interfere with development, causing defects. Examples include, alcohol, some perscription drugs, viruses, environmental chemicals etc.

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15
Q

What is Determination?

A

The commitment of a cell to a particular lineage. This may be accomplished by uneven segregation of cellular material during Mitosis or with Morphogens, which promote development down a specific cell line.

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16
Q

What is Differentiation?

A

Refers to the changes that occur in order for the cell to assume the structure and function of the determined cell type.

17
Q

What are the 3 variations of Potency?

A
  1. Totipotent
  2. Pluripotent
  3. Multipotent
18
Q

Describe Totipotency

A

Cells are able to differentiate into all cell types, including the three germ layers and placental structures.

19
Q

Describe Pluripotency

A

Cells are able to differentiate into all three germ layers and their derivatives.

20
Q

Describe Multipotency

A

Cells are able to differentiate only into a cell type within a particular lineage.

21
Q

What are the 4 types of Cell-Cell communication?

A
  1. Autocrine
  2. Paracrine
  3. Juxtacrine
  4. Endocrine
22
Q

Describe Autocrine communication

A

Acts on the same cell that releases the signals.

23
Q

Describe Paracrine commuication

A

Acts on local cells.

24
Q

Describe Juxtacrine communication

A

Triggers adjacent cells.

25
Q

Describe Endocrine communication

A

Acts on distant tissues after traveling through the bloodstream.

26
Q

What is Senescence?

A

The result of multiple molecular and metabolic processes,most notably, the shortening of telomers during cell divisions.

27
Q

What is the main function of the Placenta?

A

Serves endocrine functions, secreting estrogen, progesterone and human chronic gonadotropin (hCG).

28
Q

What is the difference between the Umbilical Arteries and the Umbilican Vein?

A

The arteries carry deoxygenated blood from the fetus to the placenta; the vein carries oxygenated blood from the placenta back to the fetus.

29
Q

What are the three shunts used in fetal circulation?

A
  1. Foramen Ovale
  2. Ductus Arteriosus
  3. Ductus Venosus
30
Q

What does the Foramen Ovale do?

A

Connects the right atrium to the left atrium, bypassing the lungs.

31
Q

What does the Ductus Arteriosus do?

A

Connects the pulmonary artery to the aorta, bypassing the lungs.

32
Q

What does the Ductus Venosus do?

A

Connects the umbilica vein to the inferior vena cava, bypassing the liver.

33
Q

What occurs during the first trimester?

A

Organogenesis occurs (development of the heart, eyes, gonads, limbs, liver, and brain). By the end of the eighth week the embryo becomes known as the fetus.

34
Q

What occurs during the second trimester?

A

Tremendous growth occurs, movement begins, the face becomes distinctly human, and the digits elongate.

35
Q

What occurs during the third trimester?

A

Rapid growth and brain development occur. There is a transfer of antibodies in the fetus.

36
Q

Describe the 3 stages of Birth

A
  1. The cervix thins out and the amniotic sac ruptures.
  2. Uterine contractions, co-ordinated by prostglandins and oxytocin, result in birth of the fetus.
  3. Placenta and umbilical cord are expelled.