Chapters 6-11 Flashcards
What does the Latin prefix “peri-“ mean?
around
What does the Latin root “chondr-“ mean?
cartilage
What is a perichondrium?
Membrane of fibrous connective tissue that covers the external surface of cartilages.
What type of tissue is perichondrium generally made of? What type of cells would you find in it?
Tissue: dense irregular connective tissue
Cells: fibroblasts and chondroblasts
what is the dominant cell type in cartilage? What are the spaces in the matrix that house these cells?
chondrocyte housed in the lacuna
Describe the structure of hyaline cartilage.
chondrocytes in the lacuna; extracellular matrix fiber is collagen unit fibril that is too thin to be seen with a light microscope.
Where in the adult body is hyaline cartilage located? Where in an embryo?
It is the most common type of cartilage located at the sternal end of the costa, in respiratory structures such as the trachea, larynx, nasal and bronchi, and at the end of long bones. In the embryo hyaline cartilage forms the embryonic skeleton - before week 8 the skeleton of the human embryo consists only of hyaline cartilage.
Describe the functional properties of hyaline cartilage. Illustrate these properties by describing a specific situation where they are important.
provides support through flexibility and resilience; firmness and flexibility; It is present at the end of long bones such as at the end of the humerus and at the ends of the radius and ulna so that when we bend our arm, the ends of the bones don’t scrape together, rather they glide smoothly.
Describe the structure of elastic cartilage.
chondrocytes in the lacuna; extracellular matrix similar to hyaline but contains many elastic fibers along with the collagen fibrils.
Describe the functional properties of elastic cartilage. Illustrate these properties by describing a specific situation where they are important.
more elastic than hyaline cartilage and better able to tolerate repeated bending; elastic fibers make it elastic. The outer ear (auricles) are elastic cartilage so that they are able to bend significantly and return to normal shape.
Where in the adult body is elastic cartilage located?
in the epiglottis at the larynx and in the outer ear (auricles)
Describe the structure of fibrocartilage.
chondrocyte in the lacuna; extracellular matrix made up of thick collagen fibers.
Describe the functional properties of fibrocartilage. Illustrate these properties by describing a specific situation where they are important.
provides firmness and resists compression like hyaline cartilage with high tensile strength to resist strong tension (pulling) forces. It is in the intervertebral discs of our spine so that when we move the disc can compress on one side while stretching on the other allowing us to bend and then return to normal resting place maintaining it’s regular shape.
Where in the adult body is fibrocartilage located?
It is located in the intervertebral discs and in the articular discs of some joints such as in the menisci of the knee.
Explain why each individual bone of the body is considered an organ.
An organ is defined as a part of the body formed of two or more tissues and adapted to carry out a specific function. The bones of the skeleton are organs because they contain several different tissues. (bone tissue, nervous tissue, blood tissue, cartilage, and epithelial tissue)
List the 5 functions of bones.
- Support
- Movement
- Protection
- Mineral storage
- Blood cell formation and energy storage
Explain how bone provides support. Illustrate your explanation with an example. Explain what it is about bone tissue that allows for this function.
Its hard, rigid framework supports the weight of the body.
Example: the bones of the legs are pillars that support the trunk of the body in the standing person. The bone is hard and rigid and does not bend.
Explain how bone permit movement. Illustrate your explanation with an example. Explain what it is about bone tissue that allows for this function.
Skeletal muscles attach to the bones by tendons and use the bones as levers to move the body and its part. Because the bone is rigid and does not bend the whole structure moves.
Example: when the muscles in our biceps contract it pulls our entire forearm up allowing us to bend our arm.
Explain how bone provides protection. Illustrate your explanation with an example. Explain what it is about bone tissue that allows for this function.
The hard rigid structure of the bone provides protection when they wrap around other more vulnerable parts of the body.
Example: the bones of the skull form a protective case for the brain.
Explain how bone provides for mineral storage. Illustrate your explanation with an example. Explain what it is about bone tissue that allows for this function.
Bones serve as a reservoir for minerals, the most important of which are calcium and phosphate. They are released into the bloodstream as ions for distribution to all parts of the body as needed.
Example: the bones stores calcium and releases it during resorption.
Explain how bones provide for cell formation and energy storage. Illustrate your explanation with an example. Explain what types of tissues are in bones that allow for these functions.
Bones contain red and yellow bone marrow. Red bone marrow (hematopoietic tissue) makes the blood cells and yellow marrow (adipose tissue) is a site of fat storage.
Describe the composition of the extracellular matrix of bone tissue.
1/3 organic components - collagen
2/3 inorganic components - hydroxyapatites (minerals) primarly calcium phosphate
Explain the different physical properties of each of the components of the matrix of bone tissue. Illustrate each by describing a specific example and explain why it is important
1/3 organic - High tensile strength, easy to bend; soft
-Allows bone to resist stretching and twisting.
2/3 inorganic - hard; rigid, incompressible, brittle
-Enables it to resist compression.
**Together (the right combination) allows bone to be exceedingly durable, strong and resilient without being brittle.
What are the three types of cells found in bone tissue? Explain what each cell type does. Illustrate the function of each cell by describing the specific activities of the cell that allow it to accomplish its specific function.
- Osteoblasts - (osteo = bone, blast = bud, sprout) “bone builder” - Cells that actively produce and secret the organic components of the bone matrix (osteoid): the ground substance and the collagen fibers.
- Osteocytes - (osteo = bone, cyte = cell) - Osteoblasts that no longer produce new osteoid and function to keep the bone matrix healthy; responds to stresses
- Osteoclasts - (osteo = bone, clast = break) - Bone destroying cell; responsible for resorption of bone. Produced from red bone marrow and secrete hydrochloric acid which dissolves the mineral component of the matrix and lysosomal enzymes which digest the organic components. (example: if not getting enough calcium, the osteoclasts will eat away at bones in order to release the reserved calcium and provide it to the body.)
What does the Latin root “osteo-“ mean?
bone
What does the Latin root “blast-“ mean? How is it used in histology?
bud, sprout - used to represent “builder”
Define the term “long bone.” Give three examples of long bones. (Be able to pick the long bones out of a list.)
Bones that are considerably longer than they are wide. They have a shaft plus two distinct ends.
- phalanges
- femur
- humerus
Define the term “short bone.” Give three examples of short bones. (Be able to pick them short bones out of a list.)
Bones that are roughly cube-shaped; occur in the wrist and ankle.
- talus
- patella
- scaphoid
Define the term “flat bone.” Give three examples of flat bones. (Be able to pick the flat bones out of a list.)
Bones that are thin, flattened, and usually somewhat curved.
- sternum
- scapula
- cranial bones (parietal, frontal, temporal, occipital)
Define the term “irregular bone.” Give three examples of irregular bones. (Be able to pick the irregular bones out of a list.)
Bones that have various shapes that do not fit into the previous categories.
- vertebrae
- hip bones
- hyoid
Explain where compact and spongy bone is found in a long bone, a flat bone, and a short bone.
- long bone - spongy bone is found at the ends of long bones (epiphysis) and the compact bone makes up the shaft (diaphysis) and outside layer of the epiphysis.
- flat bone - spongy bone sandwiched between two thin layers of compact bone.
- short bone - spongy bone surrounded by a thing layer of compact bone.
What structures would be found in a simple diagram of a typical long bone?
Shaft, proximal and distal epiphysis, epiphyseal lines, articular cartilage, medullary cavity, periosteum, endosteum
What type of tissue is found in the medullary cavity of long bones?
yellow bone marrow (adipose tissue)
What are the names of the membranes that line the outer and internal surfaces of a bone? What type of tissue are they made of? What are the functions of the membranes?
Outer surface - periosteum (“around the bone”): a connective tissue membrane that has two sublayers.
1. superficial layer of dense irregular connective tissue which resists tension plea on a bone during bending.
2. deep osteogenic layer containing bone-depositing cells (osteoblasts) and bone-destroying cells (osteoclasts) which remodel bone surfaces throughout our lives.
Internal surface - endosteum (“within the bone”): thin connective tissue membrane that covers the trabecular of spongy bone and lines the central canals of osteons. It is also osteogenic, containing both osteoblasts and osteoclasts.
What types of stresses do the two sides of a bone typically receive? Explain what it is about bone tissue that allows the bone to withstand these forces.
compression on one side and tension (stretching) on the other. To resist, the strong, compact bone tissue occurs in the external portion of the bone where stress is the greatest.
What structures would be found in a simple diagram of the microscopic anatomy of compact bone?
osteon and it’s parts: central canal, osteocytes, canaliculi, lacunae, lamellae
Explain the function of canaliculi. Explain why these structures are important.
“little canals” that run through the matrix connecting neighboring lacunae to one another and to the nearest capillaries, such as those in the central canals. Within the canaliculi the extensions of neighboring osteocytes touch each other and form gap junctions, from one osteocyte to the next. This direct transfer is the only way to supply the osteocytes with the nutrients they need because the intervening bone matrix is too solid and impermeable to act as a diffusion medium.
Name the two processes that produce bones. Briefly describe each process. Which bones of the body are formed by each of these processes?
Intramembranous ossification - membranous bones form directly form mesenchyme without first being modeled in cartilage. All bones of the skull, except a few at the base are in this category along with the clavicles.:
1. Ossification centers appear in the fibrous connective tissue membrane. (During week 8 of embryonic development) 2. Bone matrix (osteoid) is secreted within the fibrous membrane and calcifies. 3. Woven bone and periosteum form. 4. Lamellar bone replaces woven bone, just deep to the periosteum and red marrow appears.
Endochondral ossification - bones that are first modeled by hyaline cartilage, which then is gradually replaced by bone tissue. All bones from the neck down except for the clavicles are endochondral bones.:
1. Bone collar forms around the diaphysis of the hyaline cartilage model. (late embryo - 8 weeks) 2. Cartilage in the center of the diaphysis calcifies and then develops cavities. 3. The periosteal bud invades the internal cavities, ad spongy bone begins to form. 4. The diaphysis elongates and a medullary cavity forms as ossification continues. Secondary ossification centers appear in the epiphyses. 5. The epiphyses ossify. When completed, hyaline cartilage remains only in the epiphyseal plates and articular cartilages.
What would be included in a diagram of a long bone at about week 9 of development?
Hyaline cartilage, bone collar, primary ossification center
What would be included in a diagram of a long bone near birth?
1st and 2nd ossification centers, hyaline cartilage, medullary cavity, epiphyseal blood vessel, spongy bone formation, blood vessel of periosteal bud.
What would be included in a diagram of a long bone during childhood and adolescence?
Articular cartilage (hyaline), spongy bone, epiphyseal plates (hyaline cartilage), medullary cavity
What would be included in a diagram of an epiphyseal plate as found in a long bone during childhood.
resting zone, proliferation zone, hypertrophic zone, Calcification zone, ossification zone, bone, osteoblasts & osteoclasts