CHEMICAL ANALYSIS OF SPINAL FLUID CSF PROTEIN

Question 1

Normal Values of CSF PROTEIN

Answer 1

Adults = 15-45 mg/dL

Question 2

CSF protein is increased in:
Damage to the BBB: (4)
Others: (10)

Answer 2

Increased in:
Damage to the BBB:
- Meningitis
- Hemorrhage
- Increase Antibody production
- Multiple sclerosis
Others:
- Uremia, Diabetes, Cushing disease, CNS tumor, Myxedema, Polyneuritis, Connective tissue disease, Neurosyphilis, Guillain Barre syndrome

Question 3

CSF Protein is decreased in (4)

Answer 3

CSF leakage/trauma, water intoxication, Rapid CSF production, Recent puncture

Question 4

Major CSF Protein

Answer 4

Albumin

Question 5

2nd most prevalent

Answer 5

Pre albumin

Question 6

Alpha globulin

Answer 6

Haptoglobin, ceruloplasmin

Question 7

Beta-globulins

Answer 7

TAU protein:
carbohydrate-deficient transferrin; found on CSF not in serum

Question 8

Gamma globulins

Answer 8

IgG and some IgA

Question 9

Not found in normal CSF

Answer 9

IgM, Fibrinogen, Lipids