Chemo

Question 0

Platinol

Answer 0

Cisplatin (alkylating agent)
Nephrotoxic (give amifostine or manitol 25-50g ppx to prevent it)
Ototoxicity, periperal neuropathy & electrolyte abnormalities

Question 1

Vinca plant alkaloids

Answer 1

VinCristine (CNS toxicity)
VinBlastine (BMS)
Vinorelbine (Alopecia)

Never give intrathecal

Question 2

Ethyol

Answer 2

Amifostine
Cisplatin nephrotoxicity ppx
Cause severe hypotension

Question 3

Paraplatin

Answer 3

Carboplatin (analog of cisplatin)
Less nephrotoxicity
Dose base on AUC
Total dose (mg) = Target AUC x (GFR + 25)

Question 4

Myleran

Answer 4

Busulfan (Alkylating agent)

Cause: pulmonary fibrosis, hyperpigmentation, hyperuricemia (use allopurinol)

Question 5

Cytoxan

Answer 5

Cyclophosphamide
Hemorrhagic cystitis
Use Mesna

Question 6

Ifex

Answer 6

Ifosfamide
Analog of cytoxan
Hydration & Mesna

Question 7

Zanocar

Answer 7

Streptozocin

For pancreatic cancer

Question 8

Alkeran

Answer 8

Melphalan

BMS & fertility impairment

Question 9

Matulan

Answer 9

Procarbazine

Similar to MAOI & can cause disulfiram-like rxn

Question 10

Voraxaze

Answer 10

Glucarpidase

MTX antidote breaking MTX

Question 11

Xeloda

Answer 11

Capecitabine
Pro drug of 5 FU
Metastatic breast cancer resistant to paclitaxel & first line for metastatic colorectal carcinoma
2 weeks on and 1 week off

Question 12

Purinethol

Answer 12

Mercaptopurine (6 MP)

Active metabolize is metabolized by xanthine oxidase inhibitor, avoid use with allopurinol

Question 13

Fludara

Answer 13

Fludarabine

Cause significantly in imunno-suppression (AIDS in a bottle ) & toxicity (irreversible blindness)

Question 14

Adriamycin/Doxil

Answer 14

Doxorubicin
Cumulative lifetime dose: 550mg/m2
Red urine
Use zinecard (dexrazoxane) to Protect against cardiotoxicity