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BMT CN > Chemos > Flashcards

Chemos Flashcards

1
Q

Drug class of Cyclophosphamide (Cytoxan)

A

Alkylating Agent

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2
Q

Side effects of Cytoxan

A

Hemorrhagic cystitis, cardiomyopathy, SIADH, infertility

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3
Q

How to prevent hemorrhagic cystitis with Cytoxan?

A

Adequate hydration with mesna

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4
Q

With Cytoxan what lab values to monitor

A

Sodium and potassium

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5
Q

What drug class is BCNU (Carmustine)

A

Nitrosurea

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6
Q

Side effects of BCNU

A

Pulmonary fibrosis, facial burning and flushing, hypotension, HA

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7
Q

What is BCNU diluted in ?

A

Pure ethanol which causes side effects

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8
Q

Pulmonary fibrosis seen in BCNU can occur how many days post transplant? Treat with?

A

90 days, steroids

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9
Q

What class of chemo is Cytarabine (ARA-C)

A

Antimetabolite

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10
Q

Side effects of cytarabine

A

Mucositis, diarrhea, high dose can result in cerebellar toxicity, keratitis, plantar-Palmer erythema

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11
Q

What do patients getting cytarabine need to take every 6 hours?

A

Dexamethasone eye drops

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12
Q

What class of chemo is Etoposide?

A

Epipodophylotoxin

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13
Q

Side effects of etoposide

A

Hypotension, hypersensitivity reaction, mucositis, diarrhea, peripheral neuropathy, elevated LFTs

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14
Q

Side effects of undiluted etoposide

A

Hypotension, bradycardia, hypersensitivity reaction, mucositis, diarrhea

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15
Q

Undiluted etoposide monitor for what during infusion? (What could happen to med)

A

Crystallization

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16
Q

What class of chemo is melphalan

A

Alkylating agent

17
Q

Side effects with melphalon

A

Mucositis, hypersensitivity reaction, n/v, myelosuppression

18
Q

What helps mucositis when given melphalan

A

Cryotherapy (eating ice chips)

19
Q

What class of chemo is carboplastin

A

Alkylating agent

20
Q

Indications for carboplatin

A

Testicular cancer, NHL, Hodkins

21
Q

Side effects of carboplatin

A

Renal impairment, irreversible ototoxicity, electrolyte disturbances

22
Q

Class of chemo for fludarabine

A

Antimetabolite

23
Q

Side effects of fludarabine

A

Intestinal pneumonitis, n/v/d, rash

24
Q

Drug class of busulfan

A

Alkylating agent

25
Q

Side effects of busulfan

A

Hyper pigmentation, seizures, mucositis, pulmonary fibrosis, VOD

26
Q

What prophylaxis during busulfan?

A

Seizure meds (Keppra)

27
Q

What medication can’t you get during busulfan?

A

Tylenol

28
Q

What drug class is thiotepa

A

Alkylating agent

29
Q

Side effects of thiotepa

A

N/v, MSCs, VOD, pulmonary toxicity, skin desquamation

30
Q

What are some special considerations with thiotepa?

A

Patient must bathe 2-3 a day and hydrocortisone cream to underarms and other sweaty areAs

31
Q

What drug class is ATGAM/ATG

A

Lymphocyte immune globulin

32
Q

Indications for ATG

A

Immunosuppression before BMT

33
Q

side effects of ATG

A

Infusion reaction, CMV reactivation, infection, arthralgias/myalgias, HA, hypotension, serum sickeness

34
Q

Before giving ATG what must you do?

A

Inj and monitor site q 10 mins for an hour if no reaction can give IV

35
Q

TBI is usually given in fractions T or F? why or why not

A

True decreases side effects/toxicity

36
Q

Indications ofTBI

A

Leukemia, lymphoma, allo transplant

37
Q

Some side effects of TBI

A

N/v/d , mucositis, pulmonary complications, VOD, sun burn rash

38
Q

Long term TBI effects

A

GVHD, cardio toxicity, BOOP, cataracts, bone necrosis, infertility, neuro toxicity, thyroid dysfunction, growth failure

39
Q

TBI May use what on skin?

A

Aquaphor only!!!

BMT CN (2 decks)

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