chemostuff Flashcards
1
Q
DNA Methyltransferase (writer) inhibitors
A
1) Vidaza (5-Azacytidine)
2) Decitabine (5-Aza-2-deoxycytidine)
3) Zebularine (pseudo isocytosine)
- > Mimic cytosine
2
Q
Histone deacetylases (Eraser) inhibitors
A
1) Vorinostat (SAHA); Romidepsin
2) Chidamide
- > Chelate Zn
3
Q
Histone epigenetics (Reader) inhibitor
A
1) JQ1 -> BET bromodomain inhibitor
- > replaces acetyl-lysine on histones
4
Q
Histone acetylation
A
results in loose packing of nucleosomes
-> increases binding affinity of transcription factors
5
Q
DNA Writers (methylation)
A
DNMT
6
Q
DNA Methylation Erasers
A
TET
TDG
BER
7
Q
DNA Methylation Readers
A
MBD
MECP2
UHRF1
KAISO
8
Q
Tumorigenic mutation
A
MutKRAS -> Tumor growth
9
Q
Tumorigenic insulator loss
A
Leads to oncogene activation and tumor growth
