CIMS - CASE 2 Flashcards
The following can be seen in plain radiograph of patients with osteosarcoma, except:
a. destructive lesion with a moth-eaten appearance
b. spiculated periosteal reaction
c. “onion peel” periosteral reaction
d. cuff of periosteal new bone formation
C
“onion peel” - Ewing Sarcoma
MRI is used for which of the following?
a. defining bone destruction
b. pattern of calcification
c. lung metastases
d. defining soft tissue extension
D
a,b,c - CT scan
It is the most important predictive factor for long-term survival of patients with osteosarcoma
a. response to chemotherapy
b. high LDH
c. high ALP
d. response to radiotherapy
A
The following are true about osteosarcoma, except:
a. 60% of all osteosarcomas occur in children and adolescents
b. ~10% of osteosarcoma occur in the 2nd decade of life
c. osteosarcomas in the fifth and sixth decade of life are frequently secondary to either radiation therapy or transformation in a pre-existing benign condition
d. second peak of incidence exists in individuals older than 60 years
B
Most common location of osteosarcoma
a. proximal femur
b. proximal humerus
c. distal humerus
d. distal femur
D
The following are common sites of metastases for Ewing’s sarcoma
a. lung
b. bones
c. bone marrow
d. git
D
Histologic hallmark of osteosarcoma
production of malignant osteoid
Mainstay therapy for osteosarcoma
a. chemotherapy
b. radiotherapy
c. surgery
C
Which of the following is associated with favorable overall survival in patient’s with osteosarcoma?
a. miR-148
b. p16(INK4a)
c. TRPM8
B
It is the single most important study for accurate surgical staging of the lesion with use of the Enneking staging system.
a. plain radiograph
b. CT scan
c. MRI
d. bone scan
C
Hearing loss is an adverse effect of which of the following?
a. methotrexate
b. doxorubicin
c. cisplatin
d. vincristine
C
Type of osteosarcoma that frequently involves the tibia
a. telangiectatic
b. parosteal
c. conventional
d. periosteal
D
Type of osteosarcoma that contains large, blood-filled spaces
a. telangiectatic
b. parosteal
c. conventional
d. periosteal
A
Type of osteosarcoma that commonly arises in the distal posterior aspect of femur
a. telangiectatic
b. parosteal
c. conventional
d. periosteal
B
Primary tumor site with the worst prognosis
a. distal extremity
b. distal femur
c. axial skeleton
C
