Circadian rhythm and neuroendocrine regulation Flashcards
What is the key property of circadian rhytyms?
They are endogenous
What are the two problems with assessing endogenous circadian rhytyms?
Entrainment and masking (light, sleep, etc.)
How do we address the two problems?
Constant routine protocol and forced desynchrony protocol
In the constant routine protocol, there is sustained _____________, semi-recumbent posture, limited activity and ____ light
Wakefulness; dim
In forced desynchrony protocol, the subject is forced to live on a ____ cycle outside of range of entrainment
LD
The __________ is the circadian pacemaker
SCN
What are the conserved features of clock genes from bacteria to animals?
Oscillating mRNAs, proteins or activity
Autoregulatory feedback loops
What constitutes the basis of molecular clockworks?
Feedback loops
Low repression by CRY/PER leads to _______ activity of CLOCK/BMAL1
High
The tau mutations in hamsters leads to __________ PER proteins
Unstable
What mutation was found in FASPD families?
Mutation in genes encoding PER2 and CKIdelta
Where are the other clocks in the organism apart from the SCN?
Brain regions and peripheral tissues
