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Coagulation CCMLS > Coagulase Cascade > Flashcards

Coagulase Cascade Flashcards

1
Q

Intrinsic pathway

A

XII—->XIa
|
XI—–>XIa
| Ca(++)
IX—–>IX+ VIIa & PL + Ca(++)

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2
Q

Extrinsic pathway (coagulation cascade)

A

TF+ VII
|
Ca(++) + VIIa

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3
Q

Common pathway (coagulation cascade)

A

X
|
(+Intrinsic complex) Xa (+extrinsic complex)
|
Xa
|
Xa+Va & PL + Ca(++)
|
Prothrombin–>thrombin—>XII—->XIIa
Fibrinogen+thrombin—>fibrin+XIIa—> crosslinked fibrin

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4
Q

Intrinsic Xase complex

A

IX+ VIIIa
PL+ Ca(++)

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5
Q

Extrinsic Xase complex

A

Tissue factor
Ca(++) + VIIa

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6
Q

Prothrombinase complex

A

Xa + Va
PL + Ca(++)

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7
Q

I (coagulation cascade)

A

Fibrinogen

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8
Q

II (coagulation cascade)

A

Prothrombin

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9
Q

III (coagulation cascade)

A

Tissue factor

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10
Q

IV (coagulation cascade)

A

Calcium

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11
Q

V (coagulation cascade)

A

Proaccelerin

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12
Q

VII (coagulation cascade)

A

Proconvertin, stable factor

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13
Q

VIII (coagulation cascade)

A

Antihemophilic factor

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14
Q

VWF (coagulation cascade)

A

Von Willebrand factor

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15
Q

IX (coagulation cascade)

A

Plasma thromboplastin component

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16
Q

X (coagulation cascade)

A

Stuart factor

17
Q

XI (coagulation cascade)

A

Plasma thromboplastin antecedent

18
Q

XII (coagulation cascade)

A

Haegeman factor

19
Q

XIII (coagulation cascade)

A

Fibrin stabilizing factor

20
Q

HK (coagulation cascade)

A

Fitzgerald factor, Williams factor, Flaujeac factor

21
Q

PK (coagulation cascade)

A

Fletcher factor

22
Q

PL (coagulation cascade)

A

Platelet phospholipid

23
Q

TF (coagulation cascade)

A

Tissue factor

24
Q

Prothrombin group of coagulation

A

Factors: 2, 7, 9, 10
Vit K dependent

25
Q

Fibrinogen group of coagulation

A

Factors: 1, 2, 5, 8, 13
Not found in serum

26
Q

Contact group of coagulation

A

Factors: 11, 12, PK (prekallekrein), HK (high molecular weight kininogen)
Activate intrinsic pathway

27
Q

Cofactors of coagulation

A

Factors 5, 8
Cofactors of 10, 9

28
Q

Substrates of coagulation

A

Fibrinogen

29
Q

Enzymes of coagulation

A

Factors: 7, 9, 10, 11, 12
Cleave arginine/lysine
Factor 13- transglutaminase activity catalyzes formation of peptide bonds btwn glutamine & lysine on fibrin making cross links in fibrin meshwork

Coagulation CCMLS (8 decks)

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