Coagulation

Question 1

Which receptors mediate adhesion of platelets to damaged endothelium?

Answer 1

GPIb (receptor for vWF) and GPIa-IIa (receptor for collagen)

Question 2

What activates GPIb in vivo and in vitro respectively?

Answer 2

shear forces in vivo and ristocetin in vitro

Question 3

what are the components of platelet alpha granules

Answer 3

fibrinogen, platelet derived growth factor (PDGF), von willebrand factor (vWF), and platelet factor 4 (PF4)

Question 4

What are the components of dense granules

Answer 4

adenosine diphosphosphate (ADP), adenosine triphosphate (ATP), serotonin (5-HT) and calcium

Question 5

what mediates platelet aggregation

Answer 5

GPIIb/IIIa (aggregation=attachment to other platelets)

Question 6

Which factors are in the intrinsic pathway

Answer 6

XII, XI, IX, VIII, prekallikrein, high molecular weight kininogen

Question 7

What is the only factor unique to the extrinsic pathway

Answer 7

VII

Question 8

What initiates the extrinsic pathway

Answer 8

tissue factor

Question 9

what intrinsic pathway factor can VII activate

Answer 9

IX

Question 10

which factor covalently cross-links fibrin fibers

Answer 10

XIII

Question 11

what is the primary agent of fibrin degradation?

Answer 11

plasmin. plasmin is converted to plasminogen by tissue plasminogen activator (tPA)