Colorectal polyps Flashcards Preview

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Flashcards in Colorectal polyps Deck (14):
1

Description of colorectal polyps

Overgrowth of epithelial cells in the colon or rectum

2

Are they more commonly benign or malignant?

Benign

3

Most common colorectal polyps

Adenomatous polyp (colonic adenomas)

4

What gene mutation causes benign polyps

APC gene

5

What gene mutations cause malignant polyps

K-RAS and p53

6

What is FAPS

Familial adenomatous polyposis syndrome is an inherited condition where many polyps occur. Usually colon is removed as probability of malignancy is high

7

The three histological forms of adenomatous polyps

Tubular (holes), villous (tree-like) and tubulovillous (both)

8

What are the two ways to describe the histological forms

Pedunculated (has stalk membrane attachment) and sessile (firmly attached)

9

What is the most malignant combination

Sessile villous

10

Small polyps are often malignant. True or false

False. They are rarely malignant and large polyps are often malignant

11

Describe inflammatory polyps

Polyps in UC and crohns that are not malignant

12

Describe hamartomatous polyps

Mix of tissue distorted architecture, associated with juvenile polyps and peutz-jeghe's syndrome. They are usually benign

13

Risk factors for polyps

Genetic conditions, injury to bowel wall, cigarette smoke, IBD and old age.

14

How to diagnose

Usually no symptoms and discovered on colonoscopy. A biopsy is used to diagnose and a polypectomy (polyp removal)