Complement Flashcards
1
Q
What are the components of the C3 convertase?
A
C4bC2a
wiki: C4bC2b, formerly C4b2a?
1
Q
Where are components of complement produced?
A
- Largely in the liver
- Exception is c1q
2
Q
The alternative pathway
A
- c3bc3bBb= c5 convertase
- assembly of the above happens on a bacterial cell
- on our cells, this assembly is prevented by factor H and factor I (both negative regulators of the alternative pathway
3
Q
Functions of complement
A
1) Opsonization
2) Antibody production
3) Bacterial killing
4
Q
Complement deciency clinical presentation
A
5
Q
Overview of the 3 complement pathways
A
6
Q
Overview of complement disorders
A
