Complement part 4 Flashcards
(17 cards)
dissoc c1r and c1s frm c1q
c1 inh
cleaves c3b and c4b
factor I
cofactor of I to inactivate c3b; also prevent binding of b to c3b
factor h
acts as a cofactor of I to inact c4b
c4binding prot
prevents attachment of c5b67 complex to cell membranes
s-prot/vitronectin
dissoc of c3 convertase
decay accelerating factor
inh membrane attack complex
homologous restriction factor
Plasma compo regulation 7
c1 inh factor I factor h c4binding prot s-prot/vitronectin decay accelerating factor homologous restriction factor
Deficiencies of complement compo
c124 c3 c5678 c9 c1 inh daf factor h/factor i
LE like
c124
severe recurrent infxn
c3
neisser
c5678
none
c9
hereditary angioedema
c1 inh
pnh
daf
recurrent bacte infxn
factor h or i
type 1 2 3 4
1anaphylac, 2cyto, 3immune com, 4cell-mediated
1igE, 2G, 3MG, 4Sensi T cell
1baso mast, 2rbc wbc plt, 3host tissue cell, 4macro/T