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3211 pharma > coticosteroids > Flashcards

coticosteroids Flashcards

1
Q

what are 6 genomic mechanism of action of corticosteroids?

A

(monomer tethering, monomer, dimer) transactivation / transrepression

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2
Q

Gene targets decreased expression by steroids

A

TNFa (cytokine),

RANTES (chemokine),

COX2, 5 LOX, PLA2 (inflammatory enzymes),

ICAM1, VCAM1 (Adhesin molecules),

IL2R, TCR (Receptors)

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3
Q

gene targets increased expression by steroids

A

Annexin AI (PLA2 inhibitor),
B2-adrenoceptor,
IL1RA, IL1R2 (decoy receptor)
IkB-alpha (NFkB inhibitor)

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4
Q

what is the anti-inflammatory effect of corticosteroids

A

decrease circulating T/B/Monocyte/Eosinophil/Basophil, increase neutrophil, decrease size and lymphoid content of lymph node, increase macrophage efferocytosis and promotion of resolution of inflammation, decrease type IV delayed hypersensitivity reaction

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5
Q

what is the DOA/ GC/MC and Dose for prednisone (=)

A

DOA: 12-36h
GC: 4
MC: 0.3
Dose: 5mg

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6
Q

what is the DOA/ GC/MC and Dose for prednisolone (= + OH)

A

DOA: 12-35
GC: 5
MC: 0.3
Dose: 5mg

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7
Q

what is the DOA/ GC/MC and Dose for Methylprednisolone (= + CH3)

A

DOA: 12-36h
GC: 5
MC: 0
Dose: 4mg

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8
Q

what is the DOA/ GC/MC and Dose for dexamethasone (= + CH3 + F)

A

DOA: 24-72h
GC: 30
MC: 0
Dose: 0.75mg

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9
Q

what are endocrine-metabolic side effects of corticosteroids

A

hyperglycemia
muscle wasting
growth retardation (esp children)
fat redistribution (moon face, buffalo hump, truncal obesity)
hormonal disturbances
delayed wound healing, skin thinning
increased appetite, weight gain
edema

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10
Q

what are the side effects of corticosteroids on musculoskeletal system

A

osteoporosis, aseptic necrosis of femoral head, myopathy

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11
Q

what are the side effect of corticosteroids on eye and GIT

A

eye: posterior subcapsular lens cataract, glaucoma
GIT: GI bleeding, peptic ulcer (especially with NSAID)

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12
Q

what are the side effect of corticosteroids on nervous system

A

mood swing, euphoria, depression, psychosis

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13
Q

what are the side effect of corticosteroids on immune system

A

opportunistic infections due to suppression of immune cells

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14
Q

Name of corticosteroids

A

Prednisone
Prednisolone Methylprednisolone Dexamethasone

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3211 pharma (6 decks)

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