Cramming 2

Question 1

What 3 actions allow IFN’s to combat viruses?

Answer 1

1. α and β directly inhibit viral protein synth
2. γ increase MHC I and II expression
3. activate NK cells

Question 2

Which B-cell surface Ag is the receptor for EBV?

Answer 2

CD-21

Question 3

Two surface Ag’s of NK cells?

Answer 3

CD-16 and -56

Question 4

Two surface markers of MΦs?

Answer 4

CD-14 and -40

Question 5

Which cells don’t have MHC I?

Answer 5

RBCs

Question 6

How does LPS cause sepsis?

Answer 6

direct stimulation of MΦs via CD-14

Question 7

Which disease has anti-mitochondrial auto-Abs?

Answer 7

primary biliary cirrhosis

Question 8

Anti-desmoglein

Answer 8

Pemphigus vulgaris

Question 9

Anti-Jo-1

Answer 9

polymyositis, dermatomyositis

Question 10

anti-smooth muscle

Answer 10

autoimmune hepatitis

Question 11

anti-glutamate decarboxylase

Answer 11

type I DM

Question 12

What cells mediate the destruction of oligodendrocytes in MS?

Answer 12

Th1 and MΦs

Question 13

What is rheumatoid factor?

Answer 13

IgM against IgG

Question 14

Whatcluster of differentiation do Suppressor T-cells belong to?

Answer 14

CD-8+

Question 14

Rising ASO titers weeks after a streptococcal pharyngitis raises the suspicion of _______.

Answer 14

rheumatic fever