Criteria & Lists Flashcards
What are the components of the Glasgow scoring system for Pancreatitis?
Arterial oxygen less than 60mmHg. Age over 55. White cells over 15. Calcium less than 2. Urea greater than 16. LDH over 600. Albumin less than 32. Serum glucose over 10.
What is the Glasgow Scoring System for Pancreatitis?
The Glasgow system is a simple prognostic system that uses the data collected during the first 48 hours following an admission for pancreatitis. It is applicable to both biliary and alcoholic pancreatitis.
What are the 4 classic radiological features of osteoarthritis?
- Narrowed joint space
- Sclerosis
- Osteophytes
- Subchondral cysts
What are the risks of blood transfusion?
Minor allergic reaction 1/100
Major reaction 1/100,000
Hepatitis B 1/300,000
Hep C / HIV / HTLV 1/million
What are the risks of contracting HIV, Hep B, or Hep C from a single needlestick injury?
HIV : 0.3%
Hep B: 6-30%
Hep C: 1.8%
Key points in post-splenectomy counselling?
- Risk of sepsis from certain bacteria (encapsulated)
- Need vaccination within 2 weeks; repeated 3-5yrly
- Need yearly influenza vaccine
- Needs emergency antibiotics
- May need lifelong antibiotics
What is the definition of brain death?
Determination of brain death requires (irreversible):
- Unresponsive coma
- Absence of brain stem reflexes
- Absence of respiratory centre function
Describe the formal examination for diagnosis of brain death
Clinical testing is performed independently by two practitioners with specific experience and qualifications (ICU).
- Absence of responsiveness (GCS 3)
- Absence of brain stem reflexes (Pupils, Vestibulo-cochlear, Corneal reflex, Gag reflex, Cough reflex)
- Presence of apnoea (check for spontaneous breathing after generating hypercapnoea with ventilator)
Give examples of reversible causes of coma:
Hypothermia
Sedatives, anaesthetic agents, muscle relaxants, narcotics
Electrolyte abnormalities, hypoglycaemia, acidosis, alkalosis
State the rates of pseudoaneurysm for elective and therapeutic procedures:
Elective: 0.05-2%
Therapeutic: 2-8%
What are the 4 characteristics of a pseudoaneurysm?
- Atypical location
- Sudden onset
- Transmitted pulsation
- History of local trauma
What is Type I error?
Give an example:
What is an indirect index of Type I error?
Rejecting the null hypothesis when it is true (i.e a false positive)
For example:
Where Drug A doesn’t have an effect but the study says it does.
The p-value is an indirect measure of Type I error; a p-value of 0.05 means there is a 5% chance of failing to reject the true null hypothesis.
What is type II error?
Give an example:
How do you minimise Type II error?
Type II error is the failure to reject a false null hypothesis (i.e a false negative)
For example:
Where drug A does have an effect but the study says it does not.
Adequate powering of a study minimises Type II error.
Describe the Ranson criteria for pancreatitis:
A score of one for each of the following:
Age over 55 (70 GSP) WCC over 16 (18 GSP) Glucose over 11 (12.2 GSP) Serum AST over 250 Serum LDH over 400
After 48h: Calcium below 2 Ht drop of 10% Pa02 of less than 60mmHg BUN over 1.8 despite fluids Base deficit over 4 Sequestration of fluids over 6L (4L GSP)
What are the risks of mortality associated with the Ranson score?
Score 0 to 2 : 2% mortality
Score 3 to 4 : 15% mortality
Score 5 to 6 : 40% mortality
Score 7 to 8 : 100% mortality