CVP Unit 1 Lecture Flashcards
Principles of cardio vascular function include__________and the balance of it.
Supply and demand
The cells demand _______and ______, the CV system must supply with the use of ______to the cells
O2 and nutrients Blood flow
Blood flow occurs when the ______exists.
change of pressure- 🔼p
Blood flow only occurs when the pressure at one point ________ that of another.
Exceeds
If pressure was the same ______ would happen
Nothing
The heart pumps and moves blood from ______pressure to _____pressure.
Higher pressure to lower pressure
The mean arterial pressure is ______to ______and coming back is close to _____
95 to 100 Close to zero
3 things that every cell needs for survival
- 02 and nutrients 2. Removal of C02 and other metabolic wastes 3. Optimal temperature
02 is needed for ________respiration and nutrients are needed for _______.
Aerobic respiration Energy building blocks
If metabolic wastes are not removed the system becomes more ________
Acidic
Retention of ______causes _______which leads to confusion, coma, arrythmis, muscle weakness, GI disturbances.
Co2 Acidosis
Retention of ______ causes anorexia, lethargy, decreased mental acuity and death.
Urea
Optimal temp. Is important because most enzymes work at _______ body temp.
98.6
Can demands be met with diffusion?
No
Diffusion is too _______over _____distances
Too slow Long
The main purpose of the CV system is to provide a sufficiently fast mechanism of ______and _____of gasses, nutrients, wastes by use of ______.
Delivery and removal Blood flow
Diffusion is still important at the level of?
Capillaries, interstitial fluid and cell membranes
Any organ that changes the composition of the blood for the benefit of the rest of the body
Blood conditioning organs
Blood conditioning organs include:
- Lungs 2. Kidneys 3. GI Tract 4. Skin
The lungs put _____into the blood and take ____out of the blood
02 C02
Kidneys filters out ______, balance _______and eliminate hormones.
Metabolic waste Balance pH
How does the the GI tract change the composition of the blood?
Absorptions of nutrients
How does the skin condition the blood?
The skin increases or decreases the temp of the body
All blood conditioning organs have 2 things in common
- They have blood flow beyond their metabolic need 2. They can tolerate substantial drops in blood flow for short periods of time.
These organs are NOT blood conditioning organs- (3) they are considered ________ only.
- Brain 2. Muscle 3. Heart Consumers
Two things that NON blood conditioning organs have in common
- Their blood flow is regulated to be at or just above metabolic need 2. Loss of blood flow to these organs could be detrimental
Circuits help push _____through the system
Blood
There are two circuits these two circuits are?
Systemic circuit Pulmonary circuit
This circuit starts from the left ventricle goes to the body then to the right atrium
Systemic circuit
This circuit starts from the ventricles- to the lungs then to the left atrium.
Pulmonary circuit
The systemic circuit and the pulmonary circuit are in_________with eachother
Series
The systemic circuit supplies _______ which includes organs, trunk, head, and limbs in ______circulation
The body Parallel circulation
Within the systemic circuit there are 3 places where there is ______blood supply. These organs include _______, ________and _________
Serial blood supply Liver, kidney and anterior pituitary
What is the basic flow equation and what is it called?
Q=🔼P/R Ohms Law
Q=_____ 🔼P= ________ R=________
Q= flow 🔼P= change in pressure R= resistance to flow
What is the resistance equation?
When Q is up then 🔼p is ? and R is ?
🔼p is up R is down When Q is up then change of pressure is up and resistance is down.
When Q is down, 🔼p is ?? and R is ?
When Q is down, pressure is down and resistance is up.
Blood flow from the heart is also known as ______
Cardiac output
Cardiac output is usually ______liters/ pm
5 liters/pm
The source of pressure comes from the _____action of the _____
Pumping action of the heart
The heart must keep the arterial pressure ______than the _______ for flow to occur.
Greater than the venous pressure
Resistance is due to ______that impede flow
Frictions
_________radius is the main determinant of resistance especially at ______.
Blood vessel radius Arterioles
Arterioles are responsible for majority of _____
Regulation
Initial pressure mean is at ______and final pressure is _____
100mmHg 0
Blood flows along the path of ______. Organs with _____resistance receives the most flow.
Least resistance Low resistance
More flow means?
Low resistance- larger vessel
Less flow means?
High resistance Small vessel
Requirements for effective heart function include;
- Synchronized contraction of heart muscle 2. Valves open fully 3. Valves must not leak when closed 4. Contractions must be strong 5. Ventricles must fill adequetly
Circulation through the left side of the heart.
Lungs Pulmonary veins Left atrium Mitral valve ( bicuspid, AV valve) Left ventricle Aortic valve (semi lunar valve) Aorta Body
Other names for the mitral valve are?
Bicuspid AV Valve
Another name for the aortic valve
Semi lunar valve
Circulation through the right side of the heart.
IVC and SVC Right atrium Tricuspid valve (RAV valve) Right ventricle Pulmonary valve (semilunar valve) Pulmonary arteries Lungs
Another name for tricuspid valve
RAV valve
Another name for pulmonary valve
Semi lunar valve
What are the functions of the left side of the heart?
- Receives blood from the lungs 2. Pumps blood to the body
What are the functions of the right side of the heart?
- Receives blood from the body 2. Pumps blood to the lungs
Characteristics of cardiac myocytes.
- Single centrally located nucleus 2. Branched fibers 3. Striated appearance 4. Intercalated discs and gap junctions connecting adjacent cells
Then branched fibers in myocytes help to distribute ________
Force
Myocytes contract similar to ______
Skeletal muscle
Gap junctions form ______between cells
Electrical synapses
Atrial and ventricular syncytia are separated by a _________.
Fibrous septum
The fibrous septum surrounds the openings of the _______. Action potentials are _______propagated through this septum.
AV valve NOT
Within typical action potential- resting membrane potential is _______which means the inside of the cell is more _____and the outside of the cell is more _______
Polarized negative Positive
Resting potential can range from ______to ______ milivolts
50 to 90
Regarding typical AP- ___________phase is opening of Na+ channels making the inside of the cell more ______.
Depolarization phase Positive
Regarding typical AP- Repolarization phase opens _______gated ______channels where ____moves out of the cell losing the _____charge.
Repolarization phase Voltage gated K+ channels K+ Positive charge
Regarding typical AP- ________phase undershoots and then stabalizes
Hyperpolarization
Regarding typical AP- the resting membrane only becomes polarized with the AP reaches its ______
Threshold
Cardiac muscles are different because they exhibit _____ and ______ 2 properties.
Automaticity Rhythmicity
The cell can spontaneously depolarize without stimulus, its not random, happens in a regular inherent rhythm or firing rate.
Automaticity
The cells generate their own action potential without external stimulus from nerves or chemicals.
Automaticity
The cells action potential repeat at regular intervals.
Rythmicity
This cardiac muscle has the fastest firing rate.
Sinoatrial node (SA node)
Called the pacemaker
SA node
The SA Node has connections with the rest of the conduction system through _________. It controls the rate of the _______.
Intercalated discs Whole heart
The conduction system is made of specialized cells. They have very little _____ and _____ making them contract weakly.
Actin and myosin
The conduction system coordinates the ______of the atrial and ventricular contractions.
Timing
Communication between the atria and ventricles is ONLY through the _____
Bundle of HIS
The SA node is the start of the electrical system of the heart. From the SA node the ________get the signal towards the _______ which _________the signal down. Next to fire is the ______ to the ________ which is also called the _________.
internodal fibers AV node Slow AV node AV bundle Bundle of HIS
The _______or the ___________is the only connective tissue that passes through to the other side.
AV bundle or the bundle of HIS
Phase 0
Depolarization- opening of the “fast” voltage gated Na+ channels
Phase 1
Initial spike, v-gated Na+ channels inactivate
Phase 2
Plateau- v-gated Ca+ channels open slowly, these are also called Ca+ Na+ channels Decrease in K+ permeability also occurs
Phase 3
Repolarization- voltage gated Ca+ channels close, voltage gated K+ channels open
Phase 4
Resting membrane potential- active transport of Na+, K+ and Ca+
In what way does cardiac muscle and skeletal muscle action potential work in similar ways?
- Action potentials propagate along cell membrane and into T-tubules 2. Action potentials arriving in the T-tubules cause release of Ca+ from the S.R. 3. Ca+ diffuses to troponin, tropomyosin moves to allow actin/myosin cross bridges to form causing contraction.
Cardiac muscle and skeletal muscle work much the same way-
- Action potential propagates along cell membrane and into T-tubules. 2. Action potential potentials arriving in the T-tubules cause release of Ca+2 from the S.R. 3. Ca+2 diffuses to troponin, tropomyosin moves to allow actin/myosin cross bridges to form causing contraction.
The differences between cardiac muscle and skeletal muscle are?
- Cardiac S.R. Is not well developed- less capacity to store Ca+2 2. T-tubules are 5 times bigger in diameter as compared to skeletal muscle.
Cardiac cells depend greatly on extracellular ______ for initiation and strength of ______
Ca+2 Contraction