Cytoine Receptor

Question 1

what are the differnt classes of the cytokine receptor and their ligands

Answer 1

single chain - EPO and GH
gp130- IL6
bc-IL5
yc-IL2,4
ifnri/ifnrii-IFNA/B

Question 2

difference between type 1 and type 2 recepetors of cytokine receptor

Answer 2

WSXWS motif

Question 3

what is the receptor mechanism of action for the cytokine receptor

Answer 3

when the cytokine binds, the Janus Kinase, a tyrosin kinase gets phosphorylated and then the stat will be attracted and it will get phosphorylated

the stat will form dimer and then they will go on to modify gene expression

Question 4

what is the jak and stat invovled for the erythropoiethin receptor

Answer 4

jak 2 and stat 5
the receptor homodimerise

Question 5

what are the three signaling pathways for the cytokine receptors

Answer 5

jak stat
mtor- mammalian target of rapamycin
erk
pi3k

Question 6

drug invoiled in the Cytokine receptor on the jak stat coupling

Answer 6

tofacitinib against RA, PSA, and ulcerative colitis
-ruxolitib
baricitinib
oclacitinib

Question 7

what is the jak stat targeted by tofacitinib

Answer 7

jak1 and 3

Question 8

what are the regulators of the jak stat signalling

Answer 8

pias; protein inhibitors of activated STATs
SOCS: supressor of cytokine signaling
SUMO: small ubiquitin like modifiers

Question 9

what are the Tumoir necrosis factor receptro classes and ligands

Answer 9

TRNFR1,TNFR2, FAS(CD95)
RANK

TNF A
RANKL(receptor activator of NK Ab ligand

Question 10

what do the respective TNF receptor class cause, TNFR2, TNFR1, FAS

Answer 10

tnfr2, antiapoptosis,inflamatioon
tnfr1: all
fas: apoptosis and antiinflamation

Question 11

signalling pathways for the TNFR receptors for apoptosis

Answer 11

active caspase 8 and procasiapse 8 which inhibits RIP1 AND RIP3

Question 12

signalling pathways for the TNFR receptors for inflammation

Answer 12

NFKB and MAPK

Question 13

IL 1 receptor family class receptors and their ligands

Answer 13

IL1-1 - (A, B, Receptor antagonis)

also there is a IL1R11: decoy receptor

IL1-ST2 - (IL33 and soluble ST2)
IL1-36R- (A,B, Y, Receptor antagonist)
IL1-18 and IL1-A8Ra (IL18 and IL18 binding protein)

Question 14

IL1 receptor family signalling

Answer 14

MyD88: myeloid differentiation protein 88

Question 15

what are the cytokine biologic Drugs that target Erythropoietin receptor and the purpose

Answer 15

Epoitin Alfa(recominant erythropoietin) and anemia

Question 16

what are the cytokine biologic Drugs that target IL6R ad the purpose

Answer 16

Toclizumab(anti IL6R Mab) for Rheumatoid Arthritis

Question 17

what are the cytokine biologic Drugs that target IFNA/b receptor and function

Answer 17

IFNB-1a for mutiple scleorsis

Question 18

what are the cytokine biologic Drugs that target TNF A/B and function

Answer 18

infliximab(anti TNF a Mab) for Rheumatoid Arthritis

Question 19

what are the cytokine biologic Drugs that target RANKL receptor and function

Answer 19

Denosumab(anti RANKL mab) for osteoporosis

Question 20

what are the cytokine biologic Drugs that target IL1-RI receptor and function

Answer 20

anakira(rIL1RI antagnoist for Rheumatoid Arthritis