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Immunology > Cytokines > Flashcards

Cytokines Flashcards

1
Q

What does G-CSF stand for?

A

Granulocyte colony-stimulating factor

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2
Q

What cells make Granulocyte colony-stimulating factor (G-CSF)?

A

Basic tissue cell- Fibroblasts

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3
Q

What is the function of the Granulocyte colony-stimulating factor (G-CSF)?

A

Stimulates production of neutrophils and their release into the blood

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4
Q

What does IFNa stand for?

A

Interferon alpha

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5
Q

What cells make interferon-alpha (IFNa)?

A

Infected cells-usually virus

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6
Q

What is the function of interferon-alpha (IFNa)?

A

Increases anti-viral responses
Increases MCH1 levels on cells
Causes autocrine release of IFNb

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7
Q

What does IFNb stand for?

A

Interferon beta

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8
Q

What cells make Interferon-beta (IFNb)?

A

Infected cells -usually virus

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9
Q

What is the function of Interferon-beta (IFNb)?

A

Increases anti-viral responses

Increases MHC1 levels on cells

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10
Q

What does INFy stand for?

A

Interferon gamma

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11
Q

What cells make Interferon-gamma (IFNy)?

A

T cells (particulary T helper type 1)
NK cells
Intraepithelial lymphocytes in MALTs

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12
Q

What is the function of Interferon-gamma (IFNy)?

A

Activates macrophages
Increases antigen presentation on MHC2
Induces class switching of B cells
Suppresses T helper 2 (Th2) and T helper 17 (Th17) cells

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13
Q

What does IL stand for?

A

Interleukin

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14
Q

What cells make Interleukin 1 beta (IL-1b)?

A

Macrophages and epithelial cells

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15
Q

What is the function of Interleukin 1 beta (IL-1b)?

A

Proinflammatory : fever, activation of vascular endothelium to allow immune cells into tissue, T cell activation, macrophage activation

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16
Q

What cells make Interleukin 2 (IL-2)?

A

T cells

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17
Q

What is the function of Interleukin 2 (IL-2)?

A

T cell growth factor- promotes T cell proliferation and effector function

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18
Q

What cells make Interleukin 4 (IL-4)?

A

Antigen presenting cells

T helper 2 cells (Th2)

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19
Q

What is the function of Interleukin 4 (IL-4)?

A

Cause differentiation of naive T cells into Th2 cells. Th2 cells then make IL-4 which causes class switching of B cells

20
Q

What cells make Interleukin 5 (IL-5)?

A

Antigen presenting cells

Th2 cells

21
Q

What is the function of Interleukin 5 (IL-5)?

A

Like IL-4 (naive T cells into Th2 cells, which then release IL-5)
-also induces production of eosinophils

22
Q

What cells make Interleukin 6 (IL-6)?

A

Tissue cells, macrophages, endothelial cells, T cells, B cells

23
Q

What is the function of Interleukin 6 (IL-6)?

A

Proinflammatory : fever, activation of vascular endothelium to recruit immune cells
Acute phase protein production
Along with other cytokines, causes generation of Th17 and follicular helper T cells from naive T cells

24
Q

What cells make Interleukin 8 (IL-8)?

A

Macrophages, epithelial cells and other tissue cells

25
Q

What is the function of Interleukin 8 (IL-8)?

A

Chemokine !!

Attracts neutrophils into tissue

26
Q

What cells make Interleukin 10 (IL-10)?

A

Antigen presenting cells, T cells and B cells

27
Q

What is the function of Interleukin 10 (IL-10)?

A

Anti-inflammatory: suppresses responses of immune cells by stopping production of other cytokines. Induce naive T cells to become regulatory T cells

28
Q

What cells make Interleukin 12 (IL-12)?

A

Antigen presenting cells

29
Q

What is the function of Interleukin 12 (IL-12)?

A

Induces naive T cells to differentiate into Th1 cells which make IFNy

30
Q

What cells make Interleukin 13 (IL-13)?

A

Th2 cells

31
Q

What is the function of Interleukin 13 (IL-13)?

A

Helps B cell differentiation, inhibits macrophages and Th1 cells

32
Q

What cells make Interleukin 17 (IL-17)?

A

Th17 cells

33
Q

What is the function of Interleukin 17 (IL-17)?

A

Increases anti-microbial responses and pro-inflammatory cytokine production in tissues

34
Q

What cells make Interleukin 21 (IL-21)?

A

Follicular helper T cells

35
Q

What is the function of Interleukin 21 (IL-21)?

A

Maintaining germinal centre and promoting lymphocyte proliferation.
Encouraging cells to become Th17 cells

36
Q

What cells make Interleukin 22 (IL-22)?

A

Th17 cells

37
Q

What is the function of Interleukin 22 (IL-22)?

A

Increases acute phase responses and proinflammatory cytokine production in tissues

38
Q

What cells make Interleukin 23 (IL-23)?

A

Antigen presenting cells

39
Q

What is the function of Interleukin 23 (IL-23)?

A

Induces Th17 cell differentiation and proliferation

40
Q

What does TGF stand for ?

A

Transforming Growth Factor

41
Q

What cells make Transforming growth factor-beta (TGFb)?

A

Antigen presenting cells and T cells

42
Q

What is the function of Transforming growth factor-beta (TGFb)?

A

Induces Th17 cells and induces class switching to IgA

43
Q

What does TNF stand for?

A

Tumour Necrosis Factor

44
Q

What cells make Tumour necrosis factor alpha (TNFa)?

A

Macrophages, NK cells and T cells

45
Q

What os the function of Tumour necrosis factor alpha (TNFa)?

A

Proinflammatory: fever, activation of vascular endothelium to allow immune cells into tissues

Immunology (10 decks)

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