Deck 1- January Push

Question 0

Draw out arachidonic acid pathway and effects of products

Answer 0

Pg 404

Question 1

What is Mechanism of actin for aspirin?

Answer 1

Via acetylation, it irreversibly inhibits COX1 and COX2

Question 2

What is effect of aspirin? Effect on lab values PT, PTT?

Answer 2

Decrease production of TXA2 –> increase bleeding time
Decreases prostaglandins.
No effect on lab values PT, PTT

Question 3

Key points of Niacin vitamin

Answer 3

B3
NAD
From Tryptophan, requiring B6
Pellagra
Hartnup disease (decrease tryptophan), malignant carcinoid syndrome (increase tryptophan metabolism)
Isoniazid decreases B6