Flashcards in deck_5347912 Deck (18):
Aminoglycosides (Gentamicin, streptomycin)
Bind 30s irreversibly, have low oral availability, Bacteriocidal, for severe gram -ve infections, have low therapeutic index and cause nephrotoxicity and ototoxicity, Can be mutated by CAT-like enzymes.
Strength is more potent against gram negative. Broad spectrum
Last result to bind to 23 to prevent 70s translation. For Gram positive bacteria.
Target 50s and penetrate into bones to treat osteomyelitis. bu tcause colitis killing good bacteria allowing C. Diff infection
more resistant against gastric acid, more effective inoral meds.
inhibit peptidyl transferase in the 50s subunits, broad spectrum, inhibit bone marrow and grey baby syndrome. easily absorbed and distributed to treat meningitis. Resisted by CAT
Similar to methicillin, Resist beta=lactamase.
for intracell bacteria - Chlamydia and Rickettsia, Broad spectrum to bind to 30s proteins, can't use on children under 8 or pregnancy due to bone/teeth development. Resisted via pumps
Bind to PBPs such that pBps cross-link in peptidoglycan synthesis. Resisted by beta-lactamases especially carbapenmase. And Staph Aureus as well as MrSA via SCC Mec.
iNhibit type II DnA topoisomerase during DNA replication. Bacteriocidal, Fluoroquinolones - broad spectrum for anaerobes, pseudomonas, and EC bacteria. Resistance rvia mutations of topoisomerase
targets cell membrane, IV only bc of huge lipid chain, good against MRSA.
Amoxicillin and clavulanic acid.
inhibits bacterial transcriptase and treats prosthetic organ infection, tb and Leprosy. resisted via mutation of Dna dependent rna polymerase
Nitroimidazole (metronidazole Flaglyl)
binds to DNA to inhibit nucleic acid synthis, prodrug, treats C. Diff. Treats anaerobic, Flagellates, and amoebas.
works with TmP to inhibit synthesis and activates folic acid (TMP inhibits dihyrofoalte reductase) bacteriostatic - need to be hydrated, concentrate in urine, good for urine. Resisted by dihydroteroate synthetase. Strain must be resistant to both TMP and sulfanide to work.
Target 50s ribosomal proteins, bacteriodical with gram positive for VRE and VRSA. May have MLS resistance thanks to erythormycin.
Bind to 23S on 50s block translocation of ribosome and mainly for gram positive bacteria for patients alellergic to pencillin, efflux/methylation resistance