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Oral Biology II COPY > Dentin Pulp complex > Flashcards

Dentin Pulp complex Flashcards

1
Q

Dentin between roots is said to be?

A

Interadicular

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2
Q

Dentin is ____% inorganic ______% organic and _____% water

A

70, 20, 10

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3
Q

90% of the organic material in dentin is made up of what? What types?

A

Collagen (mostly I, some III and V)

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4
Q

Which 5 non collagenous proteins in dentin are also found in bone?

A 
1-Bone Sialoprotein (BSP)
2-Osteopontin (OP)
3-Osteocalcin (OC)
4-Osteonectin (ON)
5-Matrix extracellular phosphoglycoprotein
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5
Q

Which two non collagenous proteins in dentin are dentin specific?

A

1-Dentin matrix protein-1 (DMP-1)

2-Dentin Sialophosphoprotein (DSPP, cleaves into 3)

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6
Q

What 3 proteins result from cleaving of DSPP? What cleaves DSPP?

A

1-Dentin Sialoprotein (DSP)
2-Dentin phosphoprotein (DPP)
3-Dentin Glycoprotein (DG)

cleaved by BMP-1

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7
Q

Cleaved from the N terminus of DSPP by BMP-1, which dentin protein is a proteoglycan, is similar to DMP-1, is expressed in dentinal tubules and may act to prevent mineralization?

A

DSP

*loss of this results in harder, more brittle dentin

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8
Q

Cleaved from the middle of DSPP by BMP-1, which dentin protein is a glycoprotein and has an unknown function?

A

DGP

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9
Q

Cleaved from the C terminus end of DSPP by BMP-1 which dentin protein is attached to collagen, binds lots of Ca+2, and is not thought to be glycosylated?

A

DPP

*loss results in not as hard dentin

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10
Q

DSPP can cause dentinogenesis imperfecta in what two ways?

A

1-Type II- pulp chamber fills in (DSPP defect)
2-Type III- pulp enlarges, hypo-mineralization (no DSPP expression)

*Type I results from osteogenesis imperfecta where collagen I has a defect

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11
Q

odontoblasts have what origin?

A

Mesenchymal

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12
Q

What junction has a scalloped architecture?

A

DEJ

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13
Q

For what two reasons is the DEJ critical?

A

1-Defines the shape of the crown

2-Keeps dentin attached to enamel (resist shearing)

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14
Q

The first layer, closest to the DEJ is called what and is not initially tubular?

A

Mantle dentin

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15
Q

Collagen III fibrils, 0.1-0.2 mm in mantle dentin, are associated with fibronectin and are called what?

A

Von Korffs fibers

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16
Q

Odontoblasts extending into the developing matrix and secreting dentin through matrix vesicles are called what?

A

Tomes Fibers

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17
Q

What are the two types of matrix mineralization?

A

Gloublar (like paintballs)

Linear (mineralizing wall)

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18
Q

Non collagenous proteins regulate tubular primary dentin played down after DEJ formation, this dentin is called?

A

Circumpulpal

*mantle dentin is therefore the only part that is NOT tubular

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19
Q

What initiates odontoblast differentiation at the roots but does not itself become any structure and breaks into cell rests of malassez?

A

HERS

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20
Q

What are the 3 types of dentin?

A

1-Primary dentin (formed during development)
2-Secondary dentin (formed after root formation and throughout life)
3-Tertiary dentin (response to insult, is more like bone)

21
Q

When the trauma does not damage odontoblasts what subtype of tertiary dentin forms?

A

Reactionary dentin

22
Q

When trauma damages odontoblasts, causing the recruitment and differentiation of new odontoblasts what subtype of tertiary dentin forms?

A

Reparative dentin

23
Q

What are 3 main strucutures in dentin?

A

1-Dentin tubules (with OD process)
2-Peritubular dentin
3-Intertubular dentin

24
Q

What are the 4 histological zones of the pulp?

A

1-Odontoblast layer
2-Cell free zone of Weil (blood vessels and nerves)
3-Cell rich/dense zone
4-Pulp core

25
Q

What is the soft connective tissue matrix of the pulp made up of?

A
  • Collagen III mostly, some collagen I
  • proteoglycans and glycoproteins

*collagen content increases with age

26
Q

What is one main purpose of proteoglycans in the dental pulp?

A

sequester water to keep squidgy bits squidgy

27
Q

What holds the layer of odontoblasts together and makes them only slightly “leaky”?

A

Adherents junctions (tight junction, desmosomes, zonula adherens)

*serum proteins can pass, can form gap junctions with fibroblasts as well

28
Q

What 3 growth factors are in the dentin matrix ready to be released when there is damage?

A

VegF
TGF-B1
BMP-2

*GFs in dentin matrix recruit new OD

29
Q

What is the predominant cell type found in the dentin-pulp complex?

A

Fibroblasts

*mainly found in the pulp core and cell rich zone and produces/maintains matrix of pulpal tissue

30
Q

Why type of progenitor cells are present in the dental pulp?

A

Mesenchymal

31
Q

What immune cells are present in the pulp?

A

Macrophages
Dendritic cells
T and B cells ( especially in infected pulp

32
Q

The capillary network in the dental pulp is found in what region?

A

Cell free zone

*during primary dentin formation it is present in the odontoblast layer

33
Q

Where do arteries and veins enter and leave the tooth?

A

Apical foramen

*nerves and lymph enter and leave here too

34
Q

The network of nerves under the odontoblast layer especially in the coronal pulp is called what?

A

Plexus of Raschkow

35
Q

What two types of nerve fibers are in the pulp?

A

1-Afferent nerves from the trigeminal (pressure/nociception)

2-Sympathetics from superior cervical ganglion (vascular control)

36
Q

Nerve bundles consist of what two types of axons?

A

1-Myelinated “Ad” (sharp)
2-Unmyelinated “C” (throbbing)

*Myelination decreases as fibers proceed toward coronal pulp

37
Q

What are the 3 proposed models for dentin sensitivity?

A

1-Direct innervation
2-Odontoblast nociception
3-Tubule fluid conductance (hydrodynamic)

38
Q

More prevalent after 50 years of age, what pulpal feature is mineralized tissue formed in the pulp and occur around collagen fibers, dead cell aggregates or thrombi?

A

Pulp stones

39
Q

Mantle dentin is formed via what process?

A

secreted matrix vesicles rupturing to release mineralized matrix crystals. Thus it is non tubular.

40
Q

Secondary dentin is deposited in which portions of the pulpal cavity to the greatest degree?

A

roof and floor

41
Q

What shape does pre-dentin have as a result of the odontoblasts continually being more and more crowded?

A

sigmoidal

42
Q

Dentinal tubules run from what to what?

A

DEJ to the odontoblast layer of the pulp

43
Q

Which part of the dentin is highly calcified?

A

the peritubular dentin

44
Q

What is one purpose of the dentin tubules in relation to the enamel?

A

provide mechanical support to the enamel during loading

45
Q

What is the term for tubules that have become occluded via continous deposition of mineral naturally with age?

A

Sclerotic dentin

46
Q

When you see the words interglobular dentin think what?

A

areas of hypomineralized dentin

47
Q

Interglobular dentin is formed when fusion of mineral containing vesicles fails so where is it more common?

A

near the mantle dentin

48
Q

Dentin matrix is deposited continually at about what rate?

A

4um/day

49
Q

What is the term for enhanceld lines that indicate disruption of tooth formation in dentin? This term is also the dentin equivalent of striae of Retzius?

A

Contour lines of Owen

Oral Biology II COPY (15 decks)

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