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Derm > Derm 2 > Flashcards

Derm 2 Flashcards

1
Q

Secretion of Th1

A

INF gamma

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2
Q

Secretion of Th2

A

IL-4

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3
Q

Markers of T reg cells

A

Cd25

Foxp3

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4
Q

Secukinumab

A

Il 17 antagonist

Inhibits IL 17 pathway

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5
Q

Ustekinumab

A

Il12-Il23 antagonist
Binds to p40 subunit

Inhibits th1 and th17 pathways

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6
Q

Adalimumab

A

TNF alpha antagonist

Very effective against psoriatic arthritis

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7
Q

What often precedes Guttate psoriasis?

A

Stept throat

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8
Q

What may trigger pustular psoriasis?

A

Steroid withdrawal

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9
Q

Psoriasis triggers

A

Infections- esp strep pharyngitis
Worse in HIV
Smoking
Drinking

Drugs: antimalarials, beta blockers, interferon gamma, steroid withdrawal , lithium

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10
Q

Psoriasis associated diseases

A

Obiesity
Metabolic syndrome
Cardiac diseases
Irritable bowel syndrome

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11
Q

Th 17 secretes

A

Il17

Il22

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12
Q

Atopic dermatitis criteria

A 
3 of these
Pruritis
Typical morphology
Chronic or relapsing dermatitis
Personal or family history of dermatitis
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13
Q

Atrophic dermatitis associated findings

A

Hypo pigmented spots on face
Follicular accentuation
Dennie Morgan lines

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14
Q

Common mutation in children with atopic dermatitis

A

Fillagrin

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15
Q

Type 2 autoimmune reactions

A

Lupus

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16
Q

Type 4 autoimmune

A

Eczema
Erythema multiform
tEM/ Steven Johnson
Psoriasis

17
Q

Atopic triad

A

Allergies
Eczema
Asthma

18
Q

What does interleukin 1 do?

A

Activates helper T cell

19
Q

What does interleukin 2 do?

A

Stimulates cell division

20
Q

Il 22 effect upon kerotinocytes

A

Mitogenic driver

21
Q

Il 17 effect

A

Pro inflammatory

22
Q

Functions of IL9

A 
Anti tumor
Airway inflammation
Enhanced immune suppressive functions
Induces Th17 proliferation
Promotes mast cell growth
23
Q

Auspitz sign

A

Removal of a scale leads to pin point bleeding

24
Q

PUVA

A

Psoralens that intercalate into the DNA strand causing cross linking into the DNA arresting the cell cycle

25
Q

Cyclosporine

A

Immunosuppressant targeting T cells

Can only give for 1 year because of a risk of renal toxicity

26
Q

Nikolaky sign

A

Progression of the blister when pressure is added to it

It is positive in staphylococcal scalded skin syndrome

27
Q

Junction of melanocytes with kerotinocytes

A

Cadherins

28
Q

Associations of dermal melanosis

A

Head and neck spots

GNA11 and GNAQ- both code for G proteins

29
Q

Lentigo maligna melanoma

A

Chronic exposure to UV light
Located on the head and neck
Can evolve over decades

30
Q

Acral lentiginous melanoma

A

Rare- most common in people of color, but it has equal prevalence in all people

Can occur in hands, nails

31
Q

Nodular melanoma

A

Grows quickly- and vertically

Derm (3 decks)

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