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Derm > Derm > Flashcards

Derm Flashcards

1
Q

Keratin in the basal layer

A

K5/k14

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2
Q

Keratin in the spinous layer

A

K1/k10

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3
Q

Keratin in the granular layer

A

K2e

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4
Q

Keratin in the palmoplantar

A

K9

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5
Q

Keratin in hyper proliferative

A

K6/k16

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6
Q

Location of multipotent skin stem cells

A

Budge area of hair follicles

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7
Q

Keratinohyalin granules

A

Located in the granulosome layer

Contain the precursor to fillagrin which is the protein used to link keratin together

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8
Q

Glaborus skin

A

Thick skin

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9
Q

Origin and timing of melanocytes

A

Neural crest

8th week

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10
Q

Type of collagen in the lamina densa

A

Type. 4

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11
Q

What are anchoring fibrils made of?

A

Type 7 collagen

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12
Q

Melanocytes make melanin from what?

A

Tyrosine reacted with Uv

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13
Q

Staining for langerhans cells

A

S100

CD1a

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14
Q

Berbeck granules are in what cells?

A

Langerhans cells

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15
Q

Laminar vesicles

A

Contain lipids and are located in the granular layer

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16
Q

Collagens in the papillary dermis

A

Types 1 and 3

17
Q

Composition of the reticular dermis

A

Type 1 collagen and coarse elastic fibers

18
Q

Embryo origin of hair, glands, nails

A

Epidermis

19
Q

Eccrine gland Innervation

A

Sympathetic cholenergic

20
Q

Thermo sweat receptor

A

Cholenergic

21
Q

Emotional sweat receptor

A

Adrenergic

22
Q

Anagen

A

Growth phase of hair

Lasts 3 years

23
Q

Catagen

A

Involution phase of hair

2-4 weeks

24
Q

Telogen

A

Resting phase of hair Growth

3-4 months

25
Q

Beaus lines

A

Transverse lines across the nail caused by trauma to the nail matrix

26
Q

Onychomadesis

A

A severe from of beaus lines where there is complete arrest of the nail growth

27
Q

Location of melanocyte stem cells

A

Bulge of hair follicle and secondary hair germ

28
Q

Ichthyosis vulgaris

A

Defect in fillagrin
AD inheritance

Scaly skin
Associated with atopic dermatitis, sarcoidosis and hodgkins
Improves in the summer

29
Q

X linked ichthyosis

A

Steroid sulfatase def.

30
Q

Lamellar inchthyosis

A

Ar

Transglutaminase def

This enzyme is used in forming the lipid and protein envelopes during cornification

31
Q

Epidermolytic hyperkeratosis

A

AD

K1 or k10 mutation

32
Q

Epidermolysis bullosa simplex

A

AD disorder of keratin 5/14

33
Q

Junctional epidermolysis bullosa

A

AR

Laminins

Derm (3 decks)

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