diabetes

Question 1

metformin moa

Answer 1

increase secretion of GLP-1
Decrease glucagon production of the Liver
decrease uptake of glucose by intestine
increase peripheral uptake of glucose

Question 2

Metformin cardiac benefits

Answer 2

decrease chance of MI by 33%

decrease cardiac mortality by 27%

Question 3

Metformin causes lactic acid production T/F

Answer 3

False

Question 4

At what GFR is Metformin not given and also contraindicated.

Answer 4

should not be given if GFR IS < 30

Contraindicated at GFR 30 to 45

Question 5

Metformin reduces A1C by how much

Answer 5

1 to 1.5%

Question 6

How is weight impacted by Metformin

Answer 6

no weight gain

Question 7

Sulfonylureas medications 3 examples

Answer 7

glymepiride, glyburide, glipizide

Question 8

Sulfonylureas MOA

Answer 8

interact with ATP sensitive potassium channels of the pancreas beta cell membrane to increase insulin secretion.

Question 9

sulfonylureas side effects

Answer 9

hypoglycemia (*glyburide>than others)
potentiates cardiac ischemia
fractures
weight gain

Question 10

sulfonylureas reduce A1C by how much

Answer 10

1 to 1.5%

Question 11

glucose like peptide -1 (GLP-1) MOA

Answer 11

increase secretion of insulin dependent glucose
decrease glucagon production
decreases gastric motility

Question 12

GLP-1 side effects

Answer 12

weight loss
increase satiety
decrease gastric emptying

Question 13

GLP-1 decrease A1C by how much

Answer 13

1 to 1.5%

Question 14

GLP-1 is associated to what pancreatic problem

Answer 14

pancreatitis

Question 15

Dipeptidyl Peptase -4 inhibitor MOA

Answer 15

increase glucose sensitive insulin secreation

decrease glucagon secretion

Question 16

Dipeptidyl Peptase -4 inhibitor decrease A1C by how much

Answer 16

0.5 to 1%

Question 17

sodium glucose co-transport 2 inhibitor MOA

Answer 17

decrease reabsorption of renal glucose

increase excretion of renal glucose

Question 18

Sodium glucose cotransprort 2 inhibitor benefits

Answer 18

weight loss

reduce blood pressure

Question 19

Sodium glucose cotransport 2 inhibitor side effects

Answer 19

dehydration
hypovolemia
acute renal damage

Question 20

Meglitinides MOA

Answer 20

work on ATP sensitive potassium channels of pancreatic beta cells to increase release of insulin

Question 21

Which meglitinide is more effective repeglinide or nateglinide

Answer 21

repaglinide is more effective at lowering A1C

Question 22

Thiazolidinedione MOA

Answer 22

increase insulin sensitiviy of adipose tissue, skeletal muscle, and liver
decrease hepatic glucose production

Question 23

Thiazolidinedione side effects

Answer 23

weight gain, heart failure, anemia, fractures