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Farma 2 > Diabetes > Flashcards

Diabetes Flashcards

1
Q

Etiología de diabetes

A

Destruccion de las células Beta del páncreas o alteración en la resistencia a la insulina

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2
Q

Manejo de diabetes

A
  1. Metformina uso como monoterapia ( si no está contraindicada)
  2. En tx a largo plazo con metformina puede haber deficiencia de vitamina B12
  3. Iniciar con insulina en pacientes de reciente diagnóstico de DM2 sintomáticos o con HbAc1 >10 o glicemia sería > 300
  4. Si a los 3 meses de monoterapia no se ha alcanzado la meta añadir otro hipoglicemiante o insulina + hipoglicemiante
  5. Tratamiento individualizado
  6. DM2 + enfermedad ateroesclerotica o cardiovascular añadir inhibitor SGLT2
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3
Q

Fármacos usados en Diabetes

A 
Biguanidas
Sulfunilureas
Tiazolidinedionas
Inhibidor DPP-4
Inhibidor SGLT2
Agonistas de los receptores GLP1
Insulina
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4
Q

Mecanismo de acción de las BIGUANIDAS

A

Disminuye la absorción intestinal de glucosa, sensibiliza al hígado y al músculo a la acción de la insulina

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5
Q

Dosis de METFORMINA

A

500-850 mg 3 veces al día

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6
Q

Mecanismo de acción de las sulfunilureas

A

Estimulan la liberación de insulina preformada

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7
Q

Dosis de GLIBENCLAMIDA

A

Dosis:2.5-15 1-2 veces al día

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8
Q

Mecanismo de acción de las TIAZOLIDINEDIONAS

A

Aumenta la sensibilidad muscular a la insulina

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9
Q

Dosis de PIOGLITAZONA

A

Dosis: 15-45 mg 1 vez al día

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10
Q

Mecanismo de acción de los agonista de los receptores de GLP1

A

Incretinas (regulación de insulina y glucagon)

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11
Q

Dosis de LIRAGLUTIDA

A

6 mg/ml/dia

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12
Q

Mecanismo de acción de inhibidores de DPP-4

A

Aumentan los niveles de incretinas

Inhiben la dipeptil peptidasa 4

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13
Q

Dosis de SAXAGLIPTINA

A

50 mg/dia

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14
Q

Mecanismo de acción de los inhibidores de SGLT2

A

El cotransportador SGLT2 es responsable de la reabsorción del 90% de la glucosa
Disminuye la hiperglicemia postura dial

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15
Q

Dosis de DAPAGLIFLOZINA

A

5-10 mg/día

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Farma 2 (2 decks)

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