Diabetes Meds

Question 1

Janumet

Answer 1

Metformin + sitagliptin (DPP-IV inhibitor)

Question 2

Metaglip

Answer 2

Metformin + glipizide

Question 3

Glucovance

Answer 3

Metformin + glyburide

Question 4

Actoplus

Answer 4

Metformin + pioglitazone

Question 5

Avandamet

Answer 5

Metformin + rosiglitazone

Question 6

Kombiglyze

Answer 6

Metformin + saxagliptin (DPP-IV inhibitor)

Question 7

Kazano

Answer 7

Metformin + alogliptin (DPP-IV inhibitor)

Question 8

Invokamet

Answer 8

Metformin + canagliflozin

Question 9

Xigudo XR

Answer 9

Metformin + dapagliflozin

Question 10

First Generation Sulfonylureas

Answer 10

Chlorpropamide
Tolazamide
Tolbutamide

Question 11

Second Generation Sulfonylureas

Answer 11

Glipizide (Glucotrol) - shortest acting… preferred SU
Glimeperide (Amarly)
Glyburide (Diabeta) - longest acting and not preferred. Active metabolites and really cleared. Beer’s List

Question 12

Glynase

Answer 12

Micronized glyburide (longest acting second gen SU)

Question 13

Glimeperide + TZD (There are 2 of them)

Answer 13

Duetact = Glimeperide + pioglitazone
Avandaryl = Glimeperide + rosiglitazone

Question 14

Prandin

Answer 14

Repaglinide

Question 15

Starlix

Answer 15

Naeglinide (*slightly less effective than repaglinide)

Question 16

PrandiMet

Answer 16

Repaglinide + metformin

Question 17

Actos

Answer 17

Pioglitazone

Question 18

Avandia

Answer 18

Rosiglitazone

Question 19

Precose

Answer 19

Acarabose (alpha-glucosidase inhibitor)

Take with first bite of food

Question 20

Glyset

Answer 20

Miglitol (alpha-glucosidase inhibitor)

Take with first bite of food

Question 21

Januvia

Answer 21

Sitagliptin

Question 22

Onglyza

Answer 22

Saxagliptin

major 3A4 and PGP substrate (use lower dose of 2.5 mg with strong 3A4 inhibitors)

Question 23

Tradjenta

Answer 23

Linagliptin (no renal dosing)

Major 3A4 substrate

Question 24

Nesina

Answer 24

Alogliptin

Question 25

DPP-IV Inhibitor Counseling

Answer 25

Nasopharyngitis and Upper Resp Infections
Rash. Acute pancreatitis (rare. not as bad as GLP agonist)
Weight neutral!!!
Take once daily in AM with or without food
Most are really dosed

Question 26

Invokana

Answer 26

Canagliflozin

Question 27

Farxiga

Answer 27

Dapagliflozin

Increased risk of bladder cancer!

Question 28

Jardiance

Answer 28

Empagliflozin

Question 29

GLP-1 Agonists

Answer 29

Boxed warning for all (except byetta) for thyroid C cell carcinomas seen in rats.
Pancreatitis (fatal and usually in pts with risk factors: hx of pancreatitis, gallstones, alcoholism, high TGs)
Caution use in renal impairment (exenatide not recommended for CrCl

Question 30

Byetta

Bydureon

Answer 30

Exenatide (bid dosing - give within 60 min before breakfast and dinner-can be stored at RT for up to 30 days)
Exenatide ER (once weekly dosing, must be injected right after it is mixed - given without regard to meals - can be stored at RT for up to 28 days)

Question 31

Victoza

Saxenda

Answer 31

Liraglutide (daily dosing)
Liraglutide for weight loss
Can be stored at RT for up to 30 days

Question 32

Trulicity

Answer 32

Dulaglutide (once weekly doing - give without regard to meals. Can store at RT for up to 14 days)

Question 33

Tanzeum

Answer 33

Albiglutide (once weekly dosing - give without regard to meals. Can be stored at RT for 28 days) Wait 15 min after mixing for the medicine to dissolve before injecting

Question 34

Symlin

Answer 34

Pramlintide (synthetic analog of amylin)
Slows gastric emptying
Inject SQ tid