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6303 > Diabetes Meds > Flashcards

Diabetes Meds Flashcards

1
Q

Metformin Brand

A

Glucophage

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2
Q

Metformin SR Dosing

A

500mg QD to BID up to 850mg TID

Dec dose in CrCl <45

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3
Q

Metformin ER Dosing

A

Max 2000mg QD

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4
Q

Metformin MOA

A

inhibits liver from producing glucose and inc peripheral glucose uptake

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5
Q

Metformin ADR

A

GI, bloating, gas, weight loss, dec B12 levels

serious: inc acidity of blood

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6
Q

Metformin BBW

A

lactic acidosis

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7
Q

Metfromin CI

A

CrCl < 30

acute HF, contrast media

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8
Q

Glyburide Brand

A

Diabeta, Micronase, Glynase

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9
Q

Glyburide Dosing

A

1.25 to 20mg QD to BID w/ meals

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10
Q

Glipizide Brand

A

Glucotrol

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11
Q

Glipizide SR Dosing

A

5 to 40mg QD-BID 30 minutes before breakfast

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12
Q

Glipizide ER Dosing

A

2.5 to 20mg QD with breakfast

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13
Q

Glimiperide Brand

A

Amaryl

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14
Q

Glimiperide Dosing

A

1 to 8mg QD w/ meals

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15
Q

SFU MOA

A

stimulated insulin release from b cells

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16
Q

SFU ADR

A

hypoglycemia, weight gain, hypersensitivity with sulfa allergy, sun sensitivity

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17
Q

Glyburide CI

A

CrCl <50

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18
Q

Pioglitazone Brand

A

Actos

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19
Q

Pioglitazone Dosing

A

15 to 30mg QD max: 45mg

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20
Q

Rosiglitazone Brand

A

Avandia

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21
Q

Rosiglitazone Dosing

A

4mg QD

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22
Q

TZD MOA

A

enhances peripheral insulin sensitivity by activating PPARy

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23
Q

TZD ADR

A

weight gain, fluid retention, inc in bone fractures, hepatic dysfunction, CHF exacerbation

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24
Q

TZD CI

A

CHF, LFT >2.5x ULN

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25
Q

Nateglinide Brand

A

Starlix

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26
Q

Repaglinide Brand

A

Prandin

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27
Q

Meglitinides MOA

A

stimulate the rapid but short acting release of insulin

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28
Q

Meglitinides ADR

A

weight gain, hypoglycemia

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29
Q

Acarbose Brand

A

Precose

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30
Q

Miglitol Brand

A

Glycet

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31
Q

a GDI MOA

A

delay intestinal glucose absorption via inhibition of enzyme that breaks down CHO

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32
Q

a GDI ADR

A

GI, elevated LFT with A

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33
Q

a GDI CI

A

CrCl < 25, IBD

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34
Q

Exenatide Brand

A

Byetta

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35
Q

Exenatide

A

PBG, S

36
Q

Exenatide dosing

A

5mcg SQ BID then inc to 10mcg BID

60 minutes before meal

37
Q

Dulaglutide Brand

A

Trulicity

38
Q

Dulaglutide

A

FBG, L

39
Q

Dulaglutide dosing

A

.75 SQ weekly max: 1.5mg

40
Q

Liraglutide Brand

A

Victoza

41
Q

Liraglutide

A

FBG, L

42
Q

Liraglutide dosing

A

.6mg SQ weekly then inc to 1.2mg

max: 1.8

43
Q

Lixisenatide Brand

A

Adlyxin

44
Q

Lixisenatide

A

PBG, S

45
Q

Lixisenatide dosing

A

10mcg SQ QD for 14 days then 20mcg QD

46
Q

Exenatide ER Brand

A

Bydureon

47
Q

Exenatide ER

A

FBG, L

48
Q

Exenatide ER dosing

A

2mg SQ weekly

49
Q

Abiglutide Brand

A

Tanzeum

50
Q

Abiglutide

A

FBG, L

51
Q

Abiglutide dosing

A

30mg SQ weekly

max: 50mg

52
Q

GLP1 ADR

A

weight loss

serious: panceratitis, lump in throat

53
Q

Sitagliptin Brand

A

Januvia

54
Q

Sitagliptin dosing

A

100mg QD

  • 50mg CrCl 50-30 or SCr > 3 >2.5
  • 25mg CrCl <30 or SCr >3 >2.5
55
Q

Saxagliptin Brand

A

Onglyza

56
Q

Saxagliptin dosing

A

5mg QD

-2.5mg CrCl<50

57
Q

Linagliptin Brand

A

Tradjenta

58
Q

Linagliptin dosing

A

5mg QD

59
Q

Alogliptin Brand

A

Nesina

60
Q

Alogliptin dosing

A

25mg QD

  • 12.5mg CrCl 30-60
  • 6.25mg CrCl <30
61
Q

DPP4 MOA

A

inc glucose stimulated insulin secretion and glucagon suppression

62
Q

DPP4 ADR

A

severe joint pain, pancreatitis, pancreatic cancer, inc risk of HF

63
Q

Januvia and Nesina CI

A

severe hepatic insufficiency

64
Q

Canagliflozin Brand

A

Invokana

65
Q

Canagliflozin dosing

A

100mg QD up to 300mg if CrCl >60

-100mg CrCl 45 to 60

66
Q

Dapagliflozin Brand

A

Farxiga

67
Q

Dapagliflozin dosing

A

5mg QAM then inc to 10mg QAM

68
Q

Empagliflozin Brand

A

Jardiance

69
Q

Empagliflozin dosing

A

10mg QAM then inc to 25mg QAM

70
Q

Ertugliflozin brand

A

Steglatro

71
Q

Ertugliflozin dosing

A

5 and 15 mg

72
Q

SGLT2 MOA

A

blocks glucose reabsorption in the kidney and causes more glucose to be excreted

73
Q

Canagliflozin ADR

A

fungal infection, UTI

74
Q

Canagliflozin BBW

A

risk of amputation

75
Q

Canagliflozin CI

A

CrCl <45

76
Q

Dapagliflozin ADR

A

UTI, acidic blood levels

77
Q

Dapagliflozin CI

A

CrCl <60

78
Q

Empagliflozin ADR

A

mycotic infection, acidic blood levels

79
Q

Empagliflozin CI

A

CrCl <30

80
Q

Ertugliflozin CI

A

CrCl <30

81
Q

SGLT2 ADR

A

weight loss, DKA, fluid and electrolyte imbalance

82
Q

Pramlinitide Brand

A

Symlin

83
Q

Pramlinitide MOA

A

slows gastric emptying, inhibits glucagon production

84
Q

Pramlinitide ADR

A

major NV, weight loss

85
Q

Welchol CI

A

bowel obstruction, motility disorders

86
Q

Bromocriptine Brand

A

Cycloset

87
Q

Bromocriptine dosing

A
  1. 8 QD then add one tablet weekly (1.6- 4.8)

- needs to be taken within 2 hours of waking

6303 (2 decks)

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