Diseases of Unit 3 Immunology Lecture

Question 1

Septic Arthritis

Answer 1

Bacterial and viral infections. Direct invasion or deposition of microbial antigens in joints

Question 2

Rheumatoid arthritis

Answer 2

Immune response against synovial joint antigens by T cells.

Question 3

Ankylosing Spondylitis

Answer 3

Chronic inflammation of spine and sacroiliac joints

Question 4

Reiter’s syndrome

Answer 4

Inflammatory arthritis, urethritis, and conjunctivitis and uvetitis

Question 5

Psoriatic arthritis

Answer 5

?

Question 6

Anteropathic arthritis

Answer 6

Group of diseases in which an inflammatory arthritis begins before 16 years old

Question 7

SLE, systemic lupus erythematous

Question 8

Sjogren’s Syndrome

Answer 8

Autoimmune destruction of exocrine glands that include lacrimal and salivary glands. It can also include glans in respiratory mucosa and vagina. Patients can develop arthritis and connective tissue diseases.

Question 9

Scleroderma

Answer 9

Fibrosis affecting skin, GI tract, heart and muscle. Polyarthritis in 25% of patients.

Question 10

What are the mechanisms of Type 2 autoimmunity?

Answer 10

Antibody against cell surface

Question 11

What are the mechanisms of Type 3 autoimmunity?

Answer 11

Antibody forming immune complexes in tissue

Question 12

What are the mechanisms of Type 4 autoimmunity

Answer 12

Cell mediated immunity

Question 13

List type 2 autoimmunity examples

Answer 13

Autoimmune hemolytic anemia, myasthenia gravis, and Grave’s disease

Question 14

List type 3 autoimmunity examples

Answer 14

Systemic lupus erythematosus (SLE)

Question 15

List type 4 autoimmunity examples

Answer 15

Insulin - dependent diabetes mellitus, multiple sclerosis, and rheumatoid arthritis