DM

Question 1

The most replicated gene associated withT2DM encodes transcription is :

Answer 1

Factor 7 like 2 (TCF7L2)

Question 2

TCF7L2 is commonly called?

Answer 2

Diabetes gene

Question 3

Sulfonylurea are extensively metabolized by cytochrome………?

Answer 3

P450 2C9

Question 4

Plasma concentrations of glyburide and glimepiride shown to be high more in ?

Answer 4

CYP2C9 * 3

Question 5

What are the transporters of metformin

Answer 5

OCT1
OCT2
MATE1

Question 6

OCT 1 and OCT2 mediates hepatic uptake of metformin whereas MATE1 facilitate renal secretion
True or false?

Answer 6

False.

OCT 1 mediates hepatic uptake of metformin whereas OCT2 and MATE1 facilitate renal secretion

Question 7

Which ATM SNP was associated with metformin Treatment success ?

Answer 7

ATM SNP rs11212617 allele

Question 8

The most potent oral anti diabetic?

Answer 8

Sulfonylurea

Question 9

The most important polymorphism in Sulfonylurea are??

Answer 9

ABCC8 .S1369A rs75110 and KcNJ11 E23k (rs5219)

Question 10

K23/A1369 KTP will be more sensitive to inhibition by………?

Answer 10

Gliclazide