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Genoombiologie deel 1 > DNA modifications > Flashcards

DNA modifications Flashcards

1
Q

MeCPs

A

Binden aan gemethyleerde Cs

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2
Q

HDACs

A

Binden aan MeCPs en verspreiden heterochromatine

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3
Q

CpG islands

A

Hypomethylation

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4
Q

DNMT3

A

de novo methylation

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5
Q

DNMT1

A

maintenance methylation

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6
Q

H2A.z + H3K4me3

A

blokkeren de novo methylation

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7
Q

CTCF

A

insulator

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8
Q

basal bimodal

A

basele methylatie tijdens replicatie. Alles wordt gemethyleerd behalve CpG islands omdat hier RNA polymerase II bindt

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9
Q

UHRF1

A

bindt hemi meCpGs en rekruteert DNMT1

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10
Q

Polycomb repression

A

PcG complexen onderhouden methylatie, eerst binden aan repressie maar later ook zonder

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11
Q

Poised genes

A

Bivalent chromatine, kunnen aan en uit worden gezet maar staan nog uit

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Genoombiologie deel 1 (2 decks)

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