Dose optimization

Question 1

Cmax/MIC (concentration-dependent}

Answer 1

Aminoglycosides
quinolones
daptomycin

Question 2

Cmax/MIC Concentration is more important!

Answer 2

Goal: high peak ( increased killing), low trough (decreased toxicity)

Dosing strategies: large dose, long interval

Question 3

AUC/MIC (exposure-dependent)

Answer 3

Voncomycin
mocrolides
tetracyclines
polymyxins

Question 4

AUC/MIC Bug exposed to AUC is more important

Answer 4

Gool: exposure over time

Dosing strategies: variable

Question 5

Time > MIC (time>dependent)

Answer 5

Beta-lactams (penicillins, cephalosporins, carbopenems)

Question 6

Time > MIC time of exposure is more important

Answer 6

Goal: maintain drug level > MIC for most o f the dosing interval

Dosing strategies: shorter dosing interval, extended or continuous infusions