Dr. Masserano: Antianxiety Drugs Flashcards
Common Symptoms of Anxiety
- Neuromuscular
- GI
- Respiratory
- Cardiovascular
- Poor Sleep
Generalized Anxiety Disorder Treatment
1) SSRI/SNRI
2) Quetiapine, Pregabalin, Benzodiazepines
Panic Disorder Treatment
1) SSRI or SNRI
2) Mirtazapine, TCAs
Social Anxiety Disorder Treatment
1) SSRIs/SNRIs
2) Benzodiazepines, Gabapentin, Pregabalin, Beta blockers
Specific Phobia Treatment
- CBT
- SSRI
- Beta blockers
- Benzodiazepines
Agoraphobia Treatment
1) SSRIs, SNRIs, TCAs, MAOIs
2) Benzodiazepines
Separation Anxiety Disorder Treatment
- Psychotherapy
- CBT
- Counseling
- SSRIs
Obsessive Compulsive Disorder Treatment
1) SSRI
2) Antipsychotics
Buspirone (BuSpar) MoA
- Relieves anxiety
- No sedation or euphoric effects
- No rebound or withdrawal
- Minimal abuse potential
Atenolol/Clonidine/Propranolol use
- Treatment of anxiety
- Especially with symptoms of tachycardia and tremor
Which GABA Receptor Do Barbiturates Work On
- Beta subunit
- Cl enters neuron (hyperpolarizing)
Which GABA Receptor Do Benzodiazepines Work On
- Alpha subunit
- Enhances GABA receptor affinity for GABA
Flumazenil (Romazicon) MoA
-Competitive antagonist of benzodiazepine receptor
-BLACK BOX WARNING
Occurrence of seizures
Additional Uses of Benzodiazepines
1) Anticonvulsant
2) Muscle Relaxation
3) Conscious Sedation
4) Hypnotics
Midazolam (Versed) MoA
- Conscious anesthesia
- @ pH of 4 = water soluble (open ring)
- @ physiological pH = lipid soluble (closed ring)
