Drugs

Question 0

What is serotonin syndrome? How do you treat it?

Answer 0

Hyperthermia, confusion, myoclonus, cardio collapse, flushing, diarrhea

Treat: cyproheptadine

Question 1

Side effects of SSRIs?

Answer 1

1. Sexual Dysfunction

2. Serotonin Syndrome

Question 2

What is venlafaxine?

Answer 2

SNRI–blocks NE and 5-HT uptake.
Depression, GAD, Panic disorder
SE: increased BP

Question 3

What are the TCA drugs?

Answer 3

Iptyline ( Amitriptyline)
Ipramine ( clomipramine)
Doxepin
Amoxepine

Question 4

Side effects of TCA s?

Answer 4

3 Cs–coma, cardio tox, convulsions
Sedation, alpha 1 block (hypotension), anticholinergic (dry, tachy)

Worse in elderly

Question 5

What are the MAOIs?

MOA?

Answer 5

Tranylcypromine
Phenelzine
Selegiline
Isocarboxazid

MOA: inhibit monoamine oxidase and increase levels of DA, NE, 5-HT.

Question 6

What drug inhibits only MAO B?

Answer 6

Selegiline

Question 7

Side effects of MAOIs?

Answer 7

Hypertensive crisis. Especially with tyramine.

Question 8

What drug is used to treat diabetic peripheral neuropathy as well as depression?

Answer 8

Duloxetine (SNRI)

Question 9

What are the three atypical antidepressants?

Answer 9

1 Buproprion
2 Mirtazepine
3 Trazodone

Question 10

How does Mirtazepine work? What are it’s main side effects?

Answer 10

1. Alpha 2 antagonist ( increase NE, 5-HT)
2. 5-HT partial agonist

Tox: sedation, wt gain.