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Drugs > Drugs, ANS > Flashcards

Drugs, ANS Flashcards

1
Q

Somatic nervous system receptors

A

nAChR, nonselective cation channel, NMJ

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2
Q

Parasympathetic receptor

A

nAChR in ganglia and NMJ, mAChR in target cell, cholinergic

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3
Q

Sympathetic receptor

A

nACHR in ganglia, adrenergic (NE) in target cell, exception no postganglionic neuron in adrenal medulla, exception mAChR in sweat glands

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4
Q

Muscarinic receptor locations

A

M1: brain
M2: heart, eyes
M3: exocrine glands, gut, eyes, bronchioles, bladder

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5
Q

adrenergic receptor locations

A

a1: nonskeletal muscle arterioles, gut and eye sphincters, GI secretions
a2: presynaptic terminal
B1: heart
B2: skeletal muscle arterioles, lungs, gut and eye secretions
B3: bladder

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6
Q

Types of adrenergic receptors and second messengers

A

a1: Gq
a2: Gi
B1: Gs
B2: Gs
B3: Gs

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7
Q

Types of muscarinic cholinergic receptors and second messengers

A

M1: Gi
M2: Gq

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8
Q

Gq pathway

A

PLC, IP3 and DAG, Ca2+ (calmodulin, NO) and PKC

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9
Q

Gs pathway

A

Adenylyl cyclase , cAMP, PKA

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10
Q

Gi pathway

A

Blocks adenylyl cyclase, less cAMP, less PKA

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11
Q

Anticholinesterases

A

Edrophonium

Pyridostigmine

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12
Q

Botulinum toxin

A

Anti-AChE by cleaving snares

Stop: wrinkles, sweat, muscle spasms

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13
Q

Edrophonium

A

Anti-AChE, reversible

Diagnose myasthenia gravis, reverse NMJ blockade

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14
Q

Pyridostigmine

A

Anti-AChE

Treat myasthenia gravis

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15
Q

mAChR agonists

A

Cevimeline

Methacholine

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16
Q

mAChR blockers

A

Atropine

Darifenacin

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17
Q

Acetylcholine

A

Agonist of mAChR and nAChR

Used in cataract surgery

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18
Q

Succinylcholine

A

Partial nAChR agonist
Depolarizing NMJ blocker
Muscle relaxation

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19
Q

Cevimeline

A

M3-selective mAChR agonist

Increased secretions in Sjögren’s syndrome

20
Q

Methacholine

A

mAChR agonist

Diagnose airway hyperreactivity

21
Q

Tubocurarine chloride

A

Skeletal muscle nAChR competitive antagonist

NMJ relaxation

22
Q

Dantrolene

A

Blocks RYR, Ca

Reverses succinylcholine-induced malignant hyperthermia

23
Q

Atropine

A

Blocks mAChR
Mydriatic, cycloplegic
Reverses vagal bradycardia and anticholinesterase toxicity

24
Q

Darifenacin

A

M3 blocker

Incontinence, overactive bladder

25
Q

Ephedrine

A

Increases NE release

HoTN, bronchospasm, nasal decongestant

26
Q

Methyldopa

A

a2 agonist

HTN

27
Q

sympathomimetics

A

Dopamine
Epinephrine
ephedrine

28
Q

Albuterol

A

B2 agonist

Acute bronchospasm

29
Q

Clonidine

A

a2 CNS receptor agonist
Decreased sympathetic outflow
HTN

30
Q

Dobutamine

A

B1 agonist

Increase cardiac output in acute heart failure

31
Q

Dopamine

A

Adrenergic agonist

Shock, heart failure

32
Q

Epinephrine

A

Adrenergic agonist

Anaphylaxis, cardiac arrest

33
Q

Isoproterenol

A

B agonist

Acutely asthma, cardiac arrest

34
Q

Midodrine

A

a1 agonist

Chronic orthostatic hypotension

35
Q

Phenylephrine

A

a agonist

Decongestant, mydriatic, neurogenic HTN, baroreflex test

36
Q

B blocker

A

Carvedilol
Metoprolol
Propranolol

37
Q

Carvedilol

A

Adrenergic antagonist

HTN, heart failure

38
Q

Metoprolol

A

B1 antagonist

HTN, heart failure

39
Q

Phentolamine

A

a antagonist

Pheochromacytoma, adrenergic agonist overdose

40
Q

Prazosin

A

a1 antagonist

HTN, BPH

41
Q

Propranolol

A

B antagonist

Angina, arrhythmia, HTN, tremor, stage fright, migraine

42
Q

alpha blocker

A

prazosin

phentolamine

43
Q

a2 agonist

A

clonidine

methyldopa

44
Q

a1 agonist

A

midodrine

phenylephrine

45
Q

B agonist

A

dobutamine
isoproterenol
albuterol

46
Q

decongestants

A

phenylepheine

ephedrine

Drugs (5 decks)

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