Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

BFOM EXAM 2 > drugs biochem > Flashcards

drugs biochem Flashcards

1
Q

IpPLA2

A

produced by macrophages and foam cells.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

Defective Glycogen phosphorylase in muscle

A

Glycogen accumulates in skeletal muscle. Alanine cycling. Avoid anaerobic metabolism.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

AMP/Glucagon/Epinephrine on Acetyl CoA Carboxylase

A

negative modulator

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

Apo E

A

On HDL and given to VLDL and chylomicron

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

Severe Combined Immunodeficiency Disease

A
  • Increase in dATP = a decrease in lymphocytes (SCID)- 2nd most common cause due to deficient Adenosine Deaminase
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

Niemann-Pick Disease Type C

A

Inappropriate storage of cholesterol in lysosome – reduced sphingomyelinase activities

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

Phospholipase D

A

Receptor signaling, membrane transport, actin cytoskeleton.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

sPLA2

A

pancreas – emulsifcation and saponification.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

Leucovorin

A

Conjunction with 5-flucorouracil

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

3 subunits of Acetyl CoA Carboxylase (or any carboxylase)

A
  1. Biotin Carboxylase2. Biotin carboxyl Carrier protein3. Transcarboxylase
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

Phospholipase B

A

A1 and A2 activities

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

Hunter Syndrome

A

Iduronate 2 Sulfatase (MPS II), 15 years, Neuro 2-4 yo

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

Defective alpha-1,6 glucosidase

A

Glycogen accumulates, branches can’t form. Muscular dystrophy – muscle weakness

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

Defective glycogen phosphorylase in liver

A

glycogen accumulates in liver. Results in an enlarged liver. Need high protein meals.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

Citrate on Acetyl CoA Carboxylase

A

positve modulator

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

Proteoglycan

A

Glycoaminoglycans - 2 monomer. N-acetylated monosaccharide and uronate monosaccharide with one/both containing negative charges. Surface of cell/ structural integrity/ development, homeostasis, and disease.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
17
Q

Glycolipid

A

Sphingoglycolipids, Glyceroglycolipids. Cell to cell interactions, cell marker

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
18
Q

Orotic Aciduria

A

supplement forUMP Synthase defect. Use this supplement to bypass the deficiency and salvage pathways to provide pyrimidine sources

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
19
Q

Insulin on acetyl CoA carboxylase and Fatty Acid Synthase

A

positive transcription

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
20
Q

Cherry Red Spot

A

Diagnostic for Tay sachs, Sandhoffs, Fabry’s, And Neimann-Pick Disease

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
21
Q

Defective glucose-6-phosphatase

A

glycogen accumulates in the liver. lactate and alanine acummulates. High lipid and uric acid production. gout. Enlarged liver & hypoglycemia.

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
22
Q

Hydroxyurea

A

Blocks ribonucleotide reductase to treat leukemia, ovarian cancer, and melanoma

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
23
Q

Lipoprotein Lipase

A

How TAGs leave Chylomicron or VLDL

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
24
Q

Phospholipase A1

A

Spermiogensis, Vehicular transport from ER to Golgi to plasma membrane.

25
Q

Dermatan sulfate

A

Dominant in the skin matrix

26
Q

Lesch-Nyhan Syndrome

A

Complete absence of HGPRT activity. Sever gout, sever malfunctions of nervous system.

27
Q

Glycoprotein

A

N-linked, o-linked, P-linked, C-linked. Cell to Cell interactions, Cell markers, Viruses, bacteria, and parasites – entry into host cell.

28
Q

Leflunomide

A

Immunosuppressive for rheumatoid arthritis. Blocks dihydroorotase dehydrogenase.

29
Q

Defective lysosomal alpha-1,4-glucosidase

A

Glycogen can’t break down in vacuoles. Infant: Myopathy and cardiomyopathy. Adult: Progressive muscle weakness & respiratory failure

30
Q

5-Flucorouracil

A

Chemotherapeutic agent that blocks Thymidylate Synthase

31
Q

Malonyl CoA on Acetyl CoA Carboxylase

A

Negative modulator

32
Q

Hyaluronate

A

vitreous humor of the eye and synovial fluid

33
Q

Apo B100

A

On VLDL, IDL, only one on LDL

34
Q

LDL/HDL ratio predictor

A

myocardinal infection

35
Q

Gout

A

Deficient HGPRT activity, excess hypoxanthine & guanine, excess Xanthin and urate leads to build up of sodium urate crystals - Hyperuricemia. Excess PRPP synthase, Excess Inosine MP Dehyrdroganse activity. (excess purines)

36
Q

cPLA2

A

arachidonic acid

37
Q

ApoA1

A

on HDL allows with LCAT ABCA1 transporter to bring in cholesterol and phospholipids.

38
Q

Phospholipase A2

A

Vacuole storage. Arachidonic acid cut up into prostaglandins, prostacyclins, thrombaxanes, Leukotrienes

39
Q

Niemann-Pick Disease Type B

A

90% reduction in sphingomyleinase activity. No neurologic problems. Have enlarged organs.

40
Q

6-merceptopurine

A

chemotherapeutic drug and immunosupressantBlocks alpha-D-5-Phosphoribosyl-1-pyrophosphate to form Inosine monophosphate (MP).Competitive inhibitor of HGPRT, treats leukemia, Crohn’s and ulcerative colitis.

41
Q

Mycophenolate & Ribavirin

A

Organ transplant prevention & Viral. Blocks inosine MP dehydrogenase.

42
Q

Heparin

A

Anticoagulant produced in basophils and mast cells.

43
Q

Apo B48

A

On chylomicrons

44
Q

Hurler Syndrome

A

alpha-L-Iduronidase (MPSI) 10 years, neuro birth

45
Q

Apo D

A

LCAT

46
Q

Keratan SulfateChondroitin-6-sulfateChondoitin-1-sulfate

A

in tendons, cartilage, and other connective tissue

47
Q

Insulin on Citrate Lyase

A

Positive regulation

48
Q

Hyperlipoproteinemia

A

Affinity for LDL receptors decrease with loss of Apo E

49
Q

Sandhoff’s Disease

A

Globoside buildup. Creole/Metis/Lebanon. 3-6 mo motor skills slow, loss of hearing/vision & paralysis

50
Q

Label where the phospholipases cut the phospholipid

A
51
Q

APO C2

A

on HDL, gives to VLDL and Chlomicron

52
Q

Phospholipase C

A

DAG activates protein kinase C. Inositol-P3 signal transduction to open up ca2+ channel

53
Q

Tangier Disease

A

Mutations in ABCA1 with HDL deficiency

54
Q

Tay Sach’s

A

Accumulation of GM2, Jewish ancestry, Nerve damage 12-24 weeks. Death within 5 yo.

55
Q

Defect in Xanthine oxidase

A

Xanthinuria leads to renal lithiasis (kidney stones) and renal failure

56
Q

CETP

A

Exchange TAG for CE in VLDL, IDL, and HDL

57
Q

Niemann-Pick Disease Type A

A

Absence of sphingomyelinase, severe neurological condition. Death by 4 yo

58
Q

Fabry’s Disease

A

Gal before Globoside can’t cleave. Enlarged heart. Adolescence – burning sensations in the hands.

59
Q

Trimethoprim/Sulfamethoxazole

A

Antibiotic that blocks DHF reductase

BFOM EXAM 2 (4 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions