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Flashcards in drugs biochem Deck (59):
1

IpPLA2

produced by macrophages and foam cells.

2

Defective Glycogen phosphorylase in muscle

Glycogen accumulates in skeletal muscle. Alanine cycling. Avoid anaerobic metabolism.

3

AMP/Glucagon/Epinephrine on Acetyl CoA Carboxylase

negative modulator

4

Apo E

On HDL and given to VLDL and chylomicron

5

Severe Combined Immunodeficiency Disease

- Increase in dATP = a decrease in lymphocytes (SCID)- 2nd most common cause due to deficient Adenosine Deaminase

6

Niemann-Pick Disease Type C

Inappropriate storage of cholesterol in lysosome -- reduced sphingomyelinase activities

7

Phospholipase D

Receptor signaling, membrane transport, actin cytoskeleton.

8

sPLA2

pancreas -- emulsifcation and saponification.

9

Leucovorin

Conjunction with 5-flucorouracil

10

3 subunits of Acetyl CoA Carboxylase (or any carboxylase)

1. Biotin Carboxylase2. Biotin carboxyl Carrier protein3. Transcarboxylase

11

Phospholipase B

A1 and A2 activities

12

Hunter Syndrome

Iduronate 2 Sulfatase (MPS II), 15 years, Neuro 2-4 yo

13

Defective alpha-1,6 glucosidase

Glycogen accumulates, branches can't form. Muscular dystrophy -- muscle weakness

14

Defective glycogen phosphorylase in liver

glycogen accumulates in liver. Results in an enlarged liver. Need high protein meals.

15

Citrate on Acetyl CoA Carboxylase

positve modulator

16

Proteoglycan

Glycoaminoglycans - 2 monomer. N-acetylated monosaccharide and uronate monosaccharide with one/both containing negative charges. Surface of cell/ structural integrity/ development, homeostasis, and disease.

17

Glycolipid

Sphingoglycolipids, Glyceroglycolipids. Cell to cell interactions, cell marker

18

Orotic Aciduria

supplement for UMP Synthase defect. Use this supplement to bypass the deficiency and salvage pathways to provide pyrimidine sources

19

Insulin on acetyl CoA carboxylase and Fatty Acid Synthase

positive transcription

20

Cherry Red Spot

Diagnostic for Tay sachs, Sandhoffs, Fabry's, And Neimann-Pick Disease

21

Defective glucose-6-phosphatase

glycogen accumulates in the liver. lactate and alanine acummulates. High lipid and uric acid production. gout. Enlarged liver & hypoglycemia.

22

Hydroxyurea

Blocks ribonucleotide reductase  to treat leukemia, ovarian cancer, and melanoma

23

Lipoprotein Lipase

How TAGs leave Chylomicron or VLDL

24

Phospholipase A1

Spermiogensis, Vehicular transport from ER to Golgi to plasma membrane.

25

Dermatan sulfate

Dominant in the skin matrix

26

Lesch-Nyhan Syndrome

Complete absence of HGPRT activity. Sever gout, sever malfunctions of nervous system.

27

Glycoprotein

N-linked, o-linked, P-linked, C-linked. Cell to Cell interactions, Cell markers, Viruses, bacteria, and parasites -- entry into host cell.

28

Leflunomide

Immunosuppressive for rheumatoid arthritis. Blocks dihydroorotase dehydrogenase.

29

Defective lysosomal alpha-1,4-glucosidase

Glycogen can't break down in vacuoles. Infant: Myopathy and cardiomyopathy. Adult: Progressive muscle weakness & respiratory failure

30

5-Flucorouracil

Chemotherapeutic agent that blocks Thymidylate Synthase

31

Malonyl CoA on Acetyl CoA Carboxylase

Negative modulator

32

Hyaluronate

vitreous humor of the eye and synovial fluid

33

Apo B100

On VLDL, IDL, only one on LDL

34

LDL/HDL ratio predictor

myocardinal infection

35

Gout

Deficient HGPRT activity, excess hypoxanthine & guanine, excess Xanthin and urate leads to build up of sodium urate crystals - Hyperuricemia. Excess PRPP synthase, Excess Inosine MP Dehyrdroganse activity. (excess purines)

36

cPLA2

arachidonic acid

37

ApoA1

on HDL allows with LCAT ABCA1 transporter to bring in cholesterol and phospholipids.

38

Phospholipase A2

Vacuole storage. Arachidonic acid cut up into prostaglandins, prostacyclins, thrombaxanes, Leukotrienes

39

Niemann-Pick Disease Type B

90% reduction in sphingomyleinase activity. No neurologic problems. Have enlarged organs.

40

6-merceptopurine

chemotherapeutic drug and immunosupressantBlocks alpha-D-5-Phosphoribosyl-1-pyrophosphate to form Inosine monophosphate (MP).Competitive inhibitor of HGPRT, treats leukemia, Crohn's and ulcerative colitis.

41

Mycophenolate & Ribavirin

Organ transplant prevention & Viral. Blocks inosine MP dehydrogenase.

42

Heparin

Anticoagulant produced in basophils and mast cells.

43

Apo B48

On chylomicrons

44

Hurler Syndrome

alpha-L-Iduronidase (MPSI) 10 years, neuro birth

45

Apo D

LCAT

46

Keratan SulfateChondroitin-6-sulfateChondoitin-1-sulfate

in tendons, cartilage, and other connective tissue

47

Insulin on Citrate Lyase

Positive regulation

48

Hyperlipoproteinemia

Affinity for LDL receptors decrease with loss of Apo E

49

Sandhoff's Disease

Globoside buildup. Creole/Metis/Lebanon. 3-6 mo motor skills slow, loss of hearing/vision & paralysis

50

Label where the phospholipases cut the phospholipid 

51

APO C2

on HDL, gives to VLDL and Chlomicron

52

Phospholipase C

DAG activates protein kinase C. Inositol-P3 signal transduction to open up ca2+ channel

53

Tangier Disease

Mutations in ABCA1 with HDL deficiency

54

Tay Sach's

Accumulation of GM2, Jewish ancestry, Nerve damage 12-24 weeks. Death within 5 yo.

55

Defect in Xanthine oxidase

Xanthinuria leads to renal lithiasis (kidney stones) and renal failure

56

CETP

Exchange TAG for CE in VLDL, IDL, and HDL

57

Niemann-Pick Disease Type A

Absence of sphingomyelinase, severe neurological condition. Death by 4 yo

58

Fabry's Disease

Gal before Globoside can't cleave. Enlarged heart. Adolescence -- burning sensations in the hands.

59

Trimethoprim/Sulfamethoxazole

Antibiotic that blocks DHF reductase