Dysplasia

Question 1

Smokers OC risk

Answer 1

2x

Question 2

Drinker (3-4/day) OC risk

Answer 2

2x risk

Question 3

Smoker+drinker risk

Answer 3

5x risk

Question 4

Name some potentially malignant lesions

Answer 4

Leukoplakia
Erythroplakia
Candidal leukoplakia
Chronic hyperplastic candidiasis

Question 5

What is dysplasia

Answer 5

Disordered maturation in tissue

Question 6

What is dysplasia based on?

Answer 6

Atypia (changes in cellular atypia)

Question 7

What are the histological prognostic factors for a malignancy?

Answer 7

Pattern of invasion
Depth of invasion
Perineural invasion

Question 8

OC staging system

Answer 8

Site
Size (T)
Spread (N+M)

Question 9

Name the 2 lichen planus potentially malignant lesions

Answer 9

Candidal leukoplakia
Chronic hyperplastic candidiasis

Question 10

List the histopathological predictors of malignant change

Answer 10

Cellular atypia
Abnormal maturation

Question 11

List the molecular markers in oral epithelial dysplasia

Answer 11

COX1+2
HPV
Apoptosis
Angiogenesis

Question 12

Grading of Epithelial Dysplasia

Answer 12

1. Hyperplasia
2. Mild
3. Moderate
4. Severe
5. Carcinoma in situ

Question 13

Basal hyperplasia

Answer 13

Increase in basal cells
No cellular atypia

Question 14

Mild dysplasia

Answer 14

Mild atypia
Architectural changes in lower 3rd

Question 15

Moderate dysplasia

Answer 15

Moderate atypia
Architectural changes in middle 3rd

Question 16

Severe dysplasia

Answer 16

Severe atypia + numerous mitosis
Architectural changes to upper 3rd

Question 17

Carcinoma in situ

Answer 17

Abnormal architecture
Pronounced cytological atypia

Question 18

Dysplasia signs

Answer 18

Loss of polarity
Hyperchromatism
Pleomorphism