dz of stomach Flashcards
gastritis and duodenitis?
inflammation
what can cause gastritis or duodenitits?
anything that disrupts the protective factors: mucus, bicar, blood flow, prostaglandines, alkaline state, hydrophobic layer, epthelia renewal
specific causes of gastritis?
1) autoimmune disorders (pernicious anemia)-type A gastritis (body)
2) H pylori (gram neg)= type b (antrum and bo
3) Nsaids
4) stress from CNS injury, burns, sepsis, surgery
5) EtOH
what are the s/sx of gastritis?
generally reflect the underlying syndrome
+dyspepsia and abdominal pain
dx studies for gastritis?
endoscopy w/ bx
tx for gastritis?
remove causative factor, tx underlying cause
gastric neoplasms?
1) zollinger-Ellinson syndrome
2) adenocarcinoma
3) carcinod tumor
4) gastric lymphoma
what is ZES?
gastrin secreting tumor that cuases hypergastrinemia (PUD)
most found in pancreas or duodenum
what is MEN1?
multiple endocrine neoplasia type 1: autosomal condition that may cause zES
what are s/sx of zES?
PUD, abdominal pain with secretory D, occult or frank bleeding w/ anemia
dx studies of ZES?
fasting gastrin lever > 150 pg/ml
secretin test
endoscopy , CT or MRI can hlep localize tumor
tx of ZES
ppi or surgery
gastric adenocarcinoma?
older thatn 40, en
strong associattion w/ h pylori and cigarette smoking
s/sx of gastric adenocar?
dyspepsia and weigh loss associated with anemia and occult GI bleed
progressive dysphagia (neoplams on esophagus)
postprandial vomiting (neoplams near pylorus)
Virchos and SMJ nodulre
dx studies for gastric adneocarcinmoa?
- iron def anemia is most common lab finding
- liver enzymes with hepatic metastases
- CT used to determine extent of dz
