Effect of Drugs on Sleep Flashcards

1
Q

Alcohol
- sleep architecture
- REM and REM latency
- OSA?

A

Decreased sleep latency
Increased sleep disruption
Decreased REM
Increased apneas

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2
Q

Anticonvulsants

A

Increase sleepiness
Increase SWS
Decrease REM

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3
Q

Antidepressants
- REM and REM latency
- how does it affect RLS and RBD

A

Suppress REM and prolong REM latency
REM rebound may occur after withdrawal
Increased RLS and RBD

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4
Q

Antihistamines

A

Increased sedation but do not affect architecture

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5
Q

Clonidine

A

Increase slow wave sleep

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6
Q

Antipsychotics
- which medication is the exception?

A

Sedation
Increased SWS except quetiapine

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7
Q

Nicotine

A

Reduce SWS

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8
Q

Opiates

A

Reduce REM

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9
Q

Benzos

A

Reduce REM and SWS

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10
Q

Barbiturates

A

Reduce REM

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11
Q

MAOs

A

Most effective at eliminating REM

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12
Q

What part of the receptor do non benzodiazepines affect

A

Type 1 GABAa receptor

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13
Q

Caffeine

A

Reduces SWS, no effect on REM

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14
Q

Beta blockers effect on sleep

A

reduce melatonin production

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15
Q

How do Amphetamines work

A

Increase dopamine and norepi

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16
Q

Dopaminergic Agonists side effects

A

Nausea, fatigue, hypersomnia, impulsive behavior, Augmentation

17
Q

RLS treatment (1st, 2nd, 3rd line)

A

Dopaminergic agonists, then gabapentin, then opiates

18
Q

Ropinirole main side effect

A

Hypotension

19
Q

Donepezil

A

Increase in REM, decrease SWS

20
Q

Nefazodone

A

Increase REM
Increase SWS

21
Q

THC

A

Decrease REM

22
Q

Discontinuation of what medication can induce “Status Cataplexicus”

A

Anti depressants

23
Q

Gabapentin

A

Increase SWS and REM

24
Q

Steroids

A

Decrease REM

25
Q

Lithium

A

Increase SWS
Increase REM Latency

26
Q

Carbamazepine

A

Increase SWS

27
Q

Doxepin is contraindicated in…

A

narrow angle glaucoma

28
Q

Metoclopramide can worsen what sleep disorder
What is the mechanism

A

RLS due to dopamine blockade

29
Q
A