Eicosanoids Flashcards
Def
Oxygenated products of polyunsaturated long chain fatty acids.
Drugs
Prostaglandins, thromboxanes, leukotriens, lipoxin, 5hete, 5hpete
Hete and hpete
Hydroxy eicosa tetra enoic acid
Hydroxy peroxyeicosa tetra enoic acid
Cvs
Blood vessel:
Potent vasocontrictors: txa2
Vasodilator: pgI2, pge2
Heart: decreases myocardial contractility
Decreases coronary blood flow
Coronary vasoconstriction
Platelets
Inhibits platelet aggregation- pgI2, PgE2
Stimulates platelet aggregation
Txa2
Git
Smooth muscle contraction- pge2, pgf2a
Inhibition of acid and pepsin secretion: pgI2
Increase mucus, water and electrolyte secretion in the stomach: pge1 pge2
Respiratory system
Bronchoconstriction-pgd2, pgf2a, txa2, ltc4 , ltd4
Increased microvascular permeability ltc4 ltd4
Renal
Maintains auto regulation of the kidney
Increases renin release, gfr, h20, and na+ excretion
Reproductive organs
Increases uterine contraction - txa2 pge2 pgf2a
Causes uterine relaxation pgi2
Fever
Inc body temp pge2 pgf2a pgi2
Blood cells and inf
Chemoattractant for neutrophils, eosinophils, monocytes pgd2, ltb4
Inhibits lymphocytic function and immune response pgs
Decreases proliferation of t lymphocytes pge2
Activate monocytes and macrophages and inhibit eosinophils and lymphocytes- lipoxins
Clinical uses
Alprostadil
Dinoprostone
Misoprostol
Carboprost
Latanoprost
Epoprostenol
Treprosteril
Inhibitors of eicosanoids
Corticosteroids
Nsaids
Sulotroban
Zileuton
Monteleukast and zafirleukast
Serotonin
Acts on 5-HT receptors
5ht 1-7
Serotonin agonists
Buspirone
Dexfenfluramine
Triptans
Cisapride
Tegaserode
