Endocarditis Flashcards Preview

Cardiovascular Diseases > Endocarditis > Flashcards

Flashcards in Endocarditis Deck (17):
1

what is it

infection of endothelium of valves
damaged valves product turbulent flow over irritated endothelium, causing bacteria to settle producing vegetation of valve

2

what are acute symptoms

overwhelming sepsis and cardiac failure

3

what are subacute symptoms

fever
malaise
weight loss
tiredness
breathlessness

4

what is signs

fever
roth spots (retinal haemorrhages with white centres)
oslers nodes (red-purple lumps on fingers and toes)
murmur
janeway lesions (non tender, often haemorrhagic and occur on palms and aoles including base of thumb and little finger)
anaemia
splinter haemorrhages
emboli

5

what is the predisposing factors

rheumatic heart disease
mitral valve prolapse
IV drug user
prosthetic valves
congenital HD
hypertrophic cardiomyopathy

6

which organisms in mouth

viridans (alpha haemolytic strep)
bad dental hygiene or dental work

7

which organisms in native and prosthetic valve

staph aureus and staph epidermis

8

which organisms in prolonged hospitalisation

enterococci (gut)

9

which organisms in IV drug users

staph aureus

10

how is it diagnosed

blood cultures (3 sets)
serology in culture negative if still suspected
U&Es, LFTs (Alk phos raised)
FBC - raised CRP
Urine (proteinuria and haematuria)
Echo & CXR

11

which antibiotics given to native valve prior to culture results

amoxicillin, gentamicin

12

what antibiotics given to prosthetic valve prior to culture results

vancomycin, gentamicin

13

which antibiotics in staph aureus

flucloxacillin

14

what antibiotics in strep viridans

benzylpenicilin, gentamicin

15

what antibiotics in enterococcus

amoxicillin/vancomycin, gentamicin

16

what antibiotics in staph epidermis

vancomycin, gentamicin

17

what is complication

infected vegetations break off and become lodged in next capillary bed which causes abscess or haemorrhage
normally left side of heart