Endocrine disruptors II Flashcards
What are the effects of EDCs on metabolic disease?
Obesity, metabolic syndrome, diabetes mellitus, NAFLD
What are some obesogenic EDCs?
Phthalates, organotin compounds, PCBs
A possible reason for obesity is EDC-induced ____________ dysfunction
Mitochondrial
EDC-induced physiological changes in adipose tissue may also promote __________
Cancerogenesis via mutations or epigenetic changes
What are possible EDC effects contributing to metabolic disorders?
Gut microbiota alteration, mitochondrial dysfunction, circadian disruption
How are kisspeptin neurons vulnerable to estrogenic EDCs?
Kiss neurons in AVPV regulate GnRH secretion and are highly sensitive to estrogen exposure
Which reproductive disorder does EDC contribute to in men?
Testicular dygenesis syndrome - reduced sperm quality
Which EDCs affect sperm motility?
Bisphenols, PCB, phthalates
Which EDCs affect fertilization?
PCB/PBB
What hormones are affected by EDC on estradiol biosynthesis?
Progesterone, testosterone, estradiol
What effect does DES have on uterine weight?
Increase
What effect does EDC have on mammary gland development?
Altered hormone/growth factor levels and responsiveness
Which EDCs affect HPT axis?
BPA, PCB, PBDE
Which EDCs affect the thymus?
Phthalates, PCBs, BPA
Which EDCs affect the liver in HPT axis?
PCBs, dioxin, BPA, pesticides
