Endocrinology

Question 1

Zollinger Ellison Syndrome pathology

Answer 1

Zollinger-Ellison syndrome is condition characterised by excessive levels of gastrin, usually from a gastrin secreting tumour usually of the duodenum or pancreas. Around 30% occur as part of MEN type I syndrome

Question 2

Zollinger Ellison Syndrome symptoms and investigations

Answer 2

Features
•multiple gastroduodenal ulcers
•diarrhoea
•malabsorption

Diagnosis
•fasting gastrin levels: the single best screen test
•secretin stimulation test