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Cells > Enzyme Inhibition > Flashcards

Enzyme Inhibition Flashcards

1
Q

Forms of Regulation

A 
Reversible, Irreversible
Reversible covalent
Zymogens
Allosteric activation/inhibition
Compartmentalization
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2
Q

Reversible and Irreversible

A

Reversible: Competitive inhibition in Succinate Dehydrogenase in TCA cycle; Converts succinate to fumurate, but is inhibited by malonate

Irreversible: Sarin binds to serine residue in acetylcholinesterase, inhibits recycling of acetylcholine in synapses

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3
Q

Covalent modifications and Zymogens

A

Phosphorylation, eg. PDH

Zymogens, eg. pro-caspase, prothrombin

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4
Q

Allosteric inhibitors/activators

A

Eg. ATP inhibits PFK1, ADP/AMP activates PFK1

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Cells (14 decks)

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