Even more last minute.... Flashcards
What cancer is assocated with the APC gene?
Colorectal cancer…
The aPC gene normally prevents nuclear transcription.
What cancer is associated with the p53 gene?
Li-Fraumeni syndrome
Most human cancers
Codes for p21 which arrests the cell.
What cancer is associated with Rb?
Retinoblastoma
Normall blocks E2F arresting the cell.
What cancer is associated with VHL?
Von Hippel-Lindau syndrome
Normally inhibits HIF1a
VHL located on chromosome 3p and is part of the ubiquitin ligase complex.
What does the Wnt signalling pathway control?
Cell fate
Polarity
Bone marrow, skin, intestine proliferation.
What does E6 inhibit?
P53 increasing telermerase activity
What does E7 inhibit?
P53
Rb
p21
What cancers are associated with Rb gene mutations?
Retinoblastoma
Osteosarcoma
Soft tissue sarcoma
What are PSaMMoma bodies?
Pallilary thyroid and renal
Serous cystadenocarcinoma
Meningioma
Malignant mesothelioma
Chlorambucil
Busulfan
and
melphalan are all what?
Direct acting carcinogens.
What types of cancer do aromatic amines and azo dyes cause?
Carcinogenicity in the liver
What type of cancer does B-naphythylamine cause?
Bladder cancer seen in workers in aniline dye and rubber factories
What type of cancer does Aflatoxin B1 cause?
Found in fungus causes hepatocellular cancer and P53 mutations.
Estrogen increases risk of what cancer
Liver cancer
Diethyl-stilbesterol increases risk of what cancer?
Endometrial cancer, and vaginal cancer
